Yamasaki Satoshi, Masuhara Kensaku, Fuji Takeshi
Department of Orthopaedic Surgery, Osaka Kosei-Nenkin Hospital, 4-2-78, Fukushima, 553-0003, Fukushimaku, Osaka, Japan.
Int Orthop. 2004 Apr;28(2):69-73. doi: 10.1007/s00264-003-0511-4. Epub 2003 Oct 10.
We investigated the effects of tranexamic acid in 40 patients who had received cementless total hip arthroplasty (THA) in a prospective, randomized study. In 20 patients, 1000 mg of whole-body tranexamic acid was administered intravenously 5 min before the operation started. The other 20 patients served as a control group and were operated on without tranexamic acid. Perioperative blood loss was similar in the tranexamic acid group and in the control group. Postoperative blood loss of the tranexamic acid group was significantly less than that of the control group at 2, 4, 6, 8, 10, and 12 h. Regarding time-related changes of postoperative blood loss, significant reduction was observed during the first 2 h after surgery in the tranexamic acid group ( P<0.001). After the first 2 h, there was no significant difference between the tranexamic acid group and the control group. Preoperative administration of tranexamic acid decreased postoperative blood loss until 12 h and total bleeding in cementless THA by reduction of blood loss during the first 2 h after surgery.
在一项前瞻性随机研究中，我们调查了氨甲环酸对40例行非骨水泥型全髋关节置换术（THA）患者的影响。20例患者在手术开始前5分钟静脉注射1000毫克全身用氨甲环酸。另外20例患者作为对照组，未使用氨甲环酸进行手术。氨甲环酸组和对照组的围手术期失血量相似。氨甲环酸组术后2、4、6、8、10和12小时的失血量明显少于对照组。关于术后失血量的时间相关变化，氨甲环酸组在术后前2小时观察到失血量显著减少（P<0.001）。在最初2小时后，氨甲环酸组和对照组之间没有显著差异。术前给予氨甲环酸可减少术后12小时内的失血量，并通过减少术后前2小时的失血量来减少非骨水泥型THA的总出血量。
