Poppek D, Grune T
Institut für umweltmedizinische Forschung an der Heinrich-Heine-Univ. Düsseldorf, Auf'm Hennekamp 50, 40225 Düsseldorf, Germany.
Z Gerontol Geriatr. 2004 Jun;37(3):175-83. doi: 10.1007/s00391-004-0228-z.
One of the hallmarks of the aging process is the accumulation of oxidized proteins. Therefore, the accumulation of oxidized proteins is one of the key factors in the aging process. Oxidized proteins are normally repaired or degraded by the proteasomal system. This system is the most important intracellular protein degradation machinery, responsible for the degradation of oxidized proteins. For unknown reasons the removal of oxidized proteins is disturbed in aged cells. This leads to the accumulation of non-functional proteins. Further studies are needed for a better understanding of the changes in the proteasomal system and the interference with these changes.
衰老过程的一个标志是氧化蛋白质的积累。因此，氧化蛋白质的积累是衰老过程中的关键因素之一。氧化蛋白质通常由蛋白酶体系统修复或降解。该系统是细胞内最重要的蛋白质降解机制，负责氧化蛋白质的降解。由于未知原因，衰老细胞中氧化蛋白质的清除受到干扰。这导致无功能蛋白质的积累。需要进一步研究以更好地理解蛋白酶体系统的变化以及对这些变化的干扰。
