Djukanovic L, Bukvic D, Maric I
Clinic of Nephrology, Clinical Center of Serbia, Beograd, Yugoslavia.
Clin Nephrol. 2004 Jun;61(6):384-6. doi: 10.5414/cnp61384.
BACKGROUND/AIMS: Symmetrically shrunken kidneys have been considered as one of the characteristics of Balkan endemic nephropathy (BEN), but there is no agreement when the shrinking does occur in the course of the disease. In the present study, the relation between creatinine clearance (Ccr) and kidney length was compared between the patients in the early phase of BEN and other renal diseases.
The study included 84 patients with BEN (39 males, aged 54 +/- 12 years), 31 patients with other renal diseases (15 males, aged 54 +/- 14 years) and 15 healthy subjects as controls. Only the patients with Ccr above 90 ml/min were included into the study. The kidney length was measured by sonography using sector sound of 3.5 MHz.
In healthy controls and patients with renal disease other than BEN, Ccr varied between 90 and 177 ml/min, and only 3 patients had Ccr above 150 ml/min. On the contrary, 15 (18%) BEN patients had Ccr between 90 and 120 ml/min, and 37 (44%) BEN patients had Ccr above 150 ml/min. Sonographically measured kidney length of all healthy subjects and patients with renal diseases other than BEN was above 10.5 cm. Out of 84 BEN patients, 21 (25%) patients had kidney length less than 10.5 cm.
BEN patients in the early phase of the disease had significantly higher Ccr and smaller kidney in comparison to the patients with other renal diseases.
背景/目的：双侧对称性肾萎缩一直被视为巴尔干地方性肾病（BEN）的特征之一，但对于该病病程中何时出现肾萎缩尚无定论。在本研究中，比较了BEN早期患者与其他肾脏疾病患者的肌酐清除率（Ccr）和肾脏长度之间的关系。
本研究纳入了84例BEN患者（39例男性，年龄54±12岁）、31例其他肾脏疾病患者（15例男性，年龄54±14岁）以及15名健康受试者作为对照。仅将Ccr高于90 ml/min的患者纳入研究。使用3.5 MHz扇形探头通过超声测量肾脏长度。
在健康对照组和非BEN的肾脏疾病患者中，Ccr在90至177 ml/min之间，仅有3例患者的Ccr高于150 ml/min。相反，15例（18%）BEN患者的Ccr在90至120 ml/min之间，37例（44%）BEN患者的Ccr高于150 ml/min。所有健康受试者和非BEN的肾脏疾病患者的超声测量肾脏长度均超过10.5 cm。84例BEN患者中，21例（25%）患者的肾脏长度小于10.5 cm。
与其他肾脏疾病患者相比，疾病早期的BEN患者Ccr显著更高，肾脏更小。
