唾液在囊性纤维化患者铜绿假单胞菌聚集和黏附中的作用。

The role of saliva in aggregation and adherence of Pseudomonas aeruginosa in patients with cystic fibrosis.

作者信息

Tumber-Saini S K, Habbick B F, Oles A M, Schaefer J P, Komiyama K

机构信息

Department of Oral Biology, Royal University Hospital, University of Saskatchewan, Saskatoon, Canada.

出版信息

J Oral Pathol Med. 1992 Aug;21(7):299-304. doi: 10.1111/j.1600-0714.1992.tb01015.x.

DOI:10.1111/j.1600-0714.1992.tb01015.x

PMID:1522530

Abstract

The aggregation and adherence activity of P. aeruginosa, mediated by whole saliva from cystic fibrosis (CF) patients and non-CF subjects, was investigated. CF saliva-mediated aggregation of P. aeruginosa was stronger than the activity of non-CF saliva. Likewise, P. aeruginosa adherence to buccal epithelial cells (BEC) of CF patients was stronger than to BEC of non-CF subjects. Adherence of non-mucoid P. aeruginosa to BEC of CF patients was increased by saliva, whereas the mucoid variant was not. CF patients colonized with P. aeruginosa showed higher adherence of the non-mucoid variant than non-colonized CF patients. CF patients with high saliva-mediated adherence of non-mucoid P. aeruginosa also had high salivary aggregation activity. Increased CF saliva-mediated aggregation activity may be linked to the increased non-mucoid P. aeruginosa adherence to BEC of CF patients.

摘要

研究了囊性纤维化（CF）患者和非CF受试者的全唾液介导的铜绿假单胞菌的聚集和黏附活性。CF唾液介导的铜绿假单胞菌聚集比非CF唾液的活性更强。同样，铜绿假单胞菌对CF患者颊上皮细胞（BEC）的黏附比对非CF受试者BEC的黏附更强。唾液增加了非黏液型铜绿假单胞菌对CF患者BEC的黏附，而黏液型变体则不然。感染铜绿假单胞菌的CF患者中非黏液型变体的黏附高于未感染的CF患者。非黏液型铜绿假单胞菌唾液介导黏附性高的CF患者也具有高唾液聚集活性。CF唾液介导的聚集活性增加可能与非黏液型铜绿假单胞菌对CF患者BEC黏附增加有关。