水中芳香酮的加速不对称转移氢化反应
Accelerated asymmetric transfer hydrogenation of aromatic ketones in water.
作者信息
Wu Xiaofeng, Li Xiaoguang, Hems William, King Frank, Xiao Jianliang
机构信息
Liverpool Centre for Materials and Catalysis, Department of Chemistry, University of Liverpool, Liverpool, UKL69 7ZD.
出版信息
Org Biomol Chem. 2004 Jul 7;2(13):1818-21. doi: 10.1039/b403627a. Epub 2004 May 25.
DOI:10.1039/b403627a
PMID:15227530
Abstract
Asymmetric transfer hydrogenation of various simple aromatic ketones by the Ru-TsDPEN catalyst was shown to be feasible in aqueous HCOONa without calling for any catalyst modification, furnishing ee's of up to 95% and significantly faster rates than in the HCOOH-NEt(3) azeotrope.
摘要
Ru-TsDPEN催化剂对各种简单芳香酮的不对称转移氢化反应在水相HCOONa中被证明是可行的，无需对催化剂进行任何改性，得到的对映体过量值高达95%，且反应速率比在HCOOH-NEt(3)共沸物中显著更快。
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