Gao Shuanhu, Wang Qiaoling, Chen Chuo
Department of Biochemistry, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9038, USA.
J Am Chem Soc. 2009 Feb 4;131(4):1410-2. doi: 10.1021/ja808110d.
This manuscript describes a convergent synthesis and the revision of the relative stereochemistry of nakiterpiosin, a marine C-nor-D-homosteroid. Our synthesis features a late-stage carbonylative Stille cross-coupling reaction and a photo-Nazarov cyclization reaction that deliver the complete nakiterpiosin skeleton efficiently.
本手稿描述了一种海洋C-去甲-D-高甾醇类化合物nakiterpiosin的收敛合成及其相对立体化学的修正。我们的合成方法的特点是通过后期羰基化的Stille交叉偶联反应和光-Nazarov环化反应有效地构建了完整的nakiterpiosin骨架。
