nakiterpiosin的合成与结构修正
Synthesis and structure revision of nakiterpiosin.
作者信息
Gao Shuanhu, Wang Qiaoling, Chen Chuo
机构信息
Department of Biochemistry, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9038, USA.
出版信息
J Am Chem Soc. 2009 Feb 4;131(4):1410-2. doi: 10.1021/ja808110d.
Abstract
This manuscript describes a convergent synthesis and the revision of the relative stereochemistry of nakiterpiosin, a marine C-nor-D-homosteroid. Our synthesis features a late-stage carbonylative Stille cross-coupling reaction and a photo-Nazarov cyclization reaction that deliver the complete nakiterpiosin skeleton efficiently.
摘要
本手稿描述了一种海洋C-去甲-D-高甾醇类化合物nakiterpiosin的收敛合成及其相对立体化学的修正。我们的合成方法的特点是通过后期羰基化的Stille交叉偶联反应和光-Nazarov环化反应有效地构建了完整的nakiterpiosin骨架。
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