2-氰基丙烯酸乙酯组织粘合剂的吸收情况
Absorption of ethyl 2-cyanoacrylate tissue adhesive.
作者信息
Kaplan Mehmet, Oral Basak, Rollas Sevim, Kut Mustafa Sinan, Demirtas Mahmut Murat
机构信息
Department of Cardiovascular Surgery, Siyami Ersek Thoracic and Cardiovascular Surgery Center, Istanbul, Turkey.
出版信息
Eur J Drug Metab Pharmacokinet. 2004 Apr-Jun;29(2):77-81. doi: 10.1007/BF03190579.
The aim of this study was to investigate absorption of ethyl 2-cyanoacrylate glue when used as a tissue adhesive. Ethyl 2-cyanoacrylate was applied subcutaneously to four rats; its presence in blood and urine was investigated by using High Pressure Liquid Chromatography. Blood samples were drawn at baseline and after 2, 4, 6, 24, 48, 54, 78, 96 hours following application. Urine samples were obtained at baseline and after 4, 24, 48, 72, 96 hours. Administration of ethyl 2-cyanoacrylate resulted in its absorption of unchanged ethyl 2-cyanoacrylate and unknown metabolites, in plasma and urine.
本研究的目的是调查2-氰基丙烯酸乙酯胶水作为组织粘合剂时的吸收情况。将2-氰基丙烯酸乙酯皮下注射到四只大鼠体内；通过高压液相色谱法研究其在血液和尿液中的存在情况。在给药前及给药后2、4、6、24、48、54、78、96小时采集血样。在给药前及给药后4、24、48、72、96小时采集尿样。给予2-氰基丙烯酸乙酯后，其未变化的2-氰基丙烯酸乙酯及未知代谢物在血浆和尿液中被吸收。
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