3-甲氧基丁基氰基丙烯酸酯：生物相容性和生物吸收性评估

3-Methoxybutylcyanoacrylate: evaluation of biocompatibility and bioresorption.

作者信息

Henderson A M, Stephenson M

机构信息

Ethicon Ltd (a Johnson & Johnson Company), Peterborough, Ontario, Canada.

出版信息

Biomaterials. 1992;13(15):1077-84. doi: 10.1016/0142-9612(92)90140-j.

DOI:10.1016/0142-9612(92)90140-j

PMID:1493191

Abstract

The biocompatibility and bioresorption of 3-methoxybutylcyanoacrylate (MBCA) was evaluated in vivo using female Wistar albino rats. MBCA was found to elicit slight to moderate tissue reaction similar to isobutylcyanoacrylate (iBCA) which has been sold commercially as a surgical adhesive (Bucrylate, Ethicon). MBCA was judged less reactive to tissue than ethylcyanoacrylate (ECA). The MBCA implants in rat gluteal muscles also resorbed within approx. 16 wk while iBCA implants remained essentially unchanged at 36 wk in vivo. In vitro resorption in phosphate buffer (pH 7.2) at 37 degrees C showed the same trend. The MBCA performed similarly to iBCA as a haemostat on excised rat livers and as an adhesive on rat skin incisions and had comparable adhesive bond strength.

摘要

使用雌性Wistar白化大鼠在体内评估了3-甲氧基丁基氰基丙烯酸酯（MBCA）的生物相容性和生物吸收性。发现MBCA会引发轻微至中度的组织反应，类似于已作为外科手术粘合剂（Bucrylate，Ethicon）商业化销售的异丁基氰基丙烯酸酯（iBCA）。判断MBCA对组织的反应性低于乙基氰基丙烯酸酯（ECA）。大鼠臀肌中的MBCA植入物在约16周内也会吸收，而iBCA植入物在体内36周时基本保持不变。在37℃的磷酸盐缓冲液（pH 7.2）中进行的体外吸收显示出相同的趋势。MBCA作为止血剂在切除的大鼠肝脏上以及作为大鼠皮肤切口的粘合剂的表现与iBCA相似，并且具有相当的粘合强度。