口腔外科中氰基丙烯酸正丁酯的生化及组织病理学研究：一项实验性研究。
Biochemical and histopathological findings of N-butyl-2-cyanoacrylate in oral surgery: an experimental study.
作者信息
Inal Samet, Yilmaz Nergiz, Nisbet Cevat, Güvenç Tolga
机构信息
Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Ondokuz Mayis University, Samsun, Turkey.
出版信息
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006 Dec;102(6):e14-7. doi: 10.1016/j.tripleo.2006.05.001. Epub 2006 Sep 25.
OBJECTIVES
The increasing use of cyanoacrylates in dentistry, particularly as an adhesive and sealing glue, has raised concerns regarding its potential toxicity in humans. Several different forms of these compounds including methyl- (MCA), ethyl- (ECA), isobutyl-, isohexyl-, and octyl CA have been developed to eliminate tissue toxicity. N-butyl-2-cyanoacrylate is becoming an increasingly popular method for wound closure under low tension. Despite their increasing use, pharmacologic effects of these substances on liver and kidney functions are not widely known. The objective of the present study was to investigate possible immediate and long-term systemic effects of N-butyl-2-cyanoacrylate in oral surgery.
STUDY DESIGN
Ten male Wistar rats weighing 220 to 270 g were used in the study. Straight incisions were made to the buccal mucosa of the animals. N-butyl-2-cyanoacrylate adhesive (Indermil) was applied and wounds were closed primarily. Blood specimens were taken periodically from the vena cava of the animals before the surgical procedure and 2, 14, 21, and 65 days after the surgical procedure. The blood specimens of those taken before the application of the adhesive were defined as the control group; blood specimens that were taken 2, 14, 21, and 65 days from the application were defined as study group. The stored plasma samples were analyzed for blood urea nitrogen (BUN), creatinine (CRE), alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBI), total protein (TP), albumin (ALB), and amylase (AML). In addition to biochemical parameters, histopathological examination was performed. Blood parameter values of the control and study groups were statistically compared with the Duncan test (P < .05).
RESULTS
There were no significant differences in the values of BUN, CRE, ALT, AST, TBI, TP, ALB, and AML between the control and at 2, 14, 21, and 65 days.
CONCLUSION
The present study shows that N-butyl-2-cyanoacrylate is a suitable adhesive applicable in oral surgery.
目的
氰基丙烯酸酯类在牙科领域的使用日益增加，尤其是作为粘合剂和密封胶，这引发了人们对其在人体中潜在毒性的担忧。已开发出几种不同形式的这些化合物，包括甲基 - （MCA）、乙基 - （ECA）、异丁基、异己基和辛基氰基丙烯酸酯，以消除组织毒性。正丁基 - 2 - 氰基丙烯酸酯正成为一种在低张力下伤口闭合的越来越流行的方法。尽管它们的使用越来越广泛，但这些物质对肝脏和肾脏功能的药理作用尚不为人所知。本研究的目的是调查正丁基 - 2 - 氰基丙烯酸酯在口腔外科手术中可能的即时和长期全身影响。
研究设计
本研究使用了10只体重在220至270克之间的雄性Wistar大鼠。在动物的颊黏膜上做直线切口。应用正丁基 - 2 - 氰基丙烯酸酯粘合剂（Indermil）并对伤口进行一期缝合。在手术前以及手术后2、14、21和65天定期从动物的腔静脉采集血样。将在应用粘合剂之前采集的血样定义为对照组；在应用后2、14、21和65天采集的血样定义为研究组。对储存的血浆样本进行血尿素氮（BUN）、肌酐（CRE）、丙氨酸转氨酶（ALT）、天冬氨酸转氨酶（AST）、总胆红素（TBI）、总蛋白（TP）、白蛋白（ALB）和淀粉酶（AML）分析。除了生化参数外，还进行了组织病理学检查。对照组和研究组的血液参数值通过邓肯检验进行统计学比较（P < 0.05）。
结果
对照组与术后2、14、21和65天的BUN、CRE、ALT、AST、TBI、TP、ALB和AML值之间无显著差异。
结论
本研究表明正丁基 - 2 - 氰基丙烯酸酯是一种适用于口腔外科手术的粘合剂。
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