Mrabet Hela, Mrabet Amel, Zouari Bechir, Ghachem Rim
Department of Neurology, Charles Nicolle Hospital, Tunis, Tunisia.
Epilepsia. 2004 Jul;45(7):838-43. doi: 10.1111/j.0013-9580.2004.56903.x.
The goal of the study was to assess the health-related quality of life (HRQOL) of persons with epilepsy (PWE) by using the short form survey 36 (SF-36), to compare it with that of a control group and to detect factors influencing it.
We collected clinical and demographic data and information on health status by using the Arabic translation of the SF-36 questionnaire from two groups: (a) 120 PWE consulting our outpatient clinic during a period of 4 months, and (b) 110 Tunisian citizens, representative of the Tunisian general population, as a control group.
The mean age of PWE group was 32.74 years, and 45.5% were men. Idiopathic generalized epilepsies were observed in 44.5% of cases, and symptomatic partial epilepsies, in 30%. The most commonly prescribed drug was sodium valproate (VPA). For the SF-36, PWE had lower scores than the control group for only three subscales: general health perception, mental health, and social functioning. Seizure frequency, time since last seizure, and the antiepileptic drug (AED) side effects were the most important variables influencing the HRQOL among PWE. Seizure-free adults have HRQOL levels comparable to those of the control group. Sociodemographic variables had no influence on the SF-36 subscales.
HRQOL is impaired in Tunisian PWE. The influencing factors identified in this study differ from the previously published data. Several possible reasons such as family support and cultural and religious beliefs are proposed to explain these cross-cultural differences. A larger study should be conducted to verify such findings.
本研究的目的是通过使用简短健康调查问卷36（SF - 36）评估癫痫患者（PWE）的健康相关生活质量（HRQOL），将其与对照组进行比较，并检测影响该质量的因素。
我们通过使用SF - 36问卷的阿拉伯语翻译收集了两组的临床、人口统计学数据以及健康状况信息：（a）在4个月期间到我们门诊就诊的120名癫痫患者，以及（b）作为对照组的110名代表突尼斯普通人群的突尼斯公民。
癫痫患者组的平均年龄为32.74岁，45.5%为男性。44.5%的病例观察到特发性全身性癫痫，30%为症状性部分性癫痫。最常开具的药物是丙戊酸钠（VPA）。对于SF - 36，癫痫患者仅在三个子量表上得分低于对照组：总体健康感知、心理健康和社会功能。癫痫发作频率、上次发作后的时间以及抗癫痫药物（AED）副作用是影响癫痫患者HRQOL的最重要变量。无癫痫发作的成年人的HRQOL水平与对照组相当。社会人口统计学变量对SF - 36子量表没有影响。
突尼斯癫痫患者的HRQOL受损。本研究中确定的影响因素与先前发表的数据不同。提出了一些可能的原因，如家庭支持以及文化和宗教信仰，以解释这些跨文化差异。应进行更大规模的研究来验证这些发现。
