Park Ock Jin, Kang Nam E, Chang Moon Jeong, Kim Woo Kyoung
Department of Food and Nutrition, Hannam University, 133 Ojeong-Dong, Daedeok-Gu, Daejeon 306-791, Korea.
J Nutr Sci Vitaminol (Tokyo). 2004 Apr;50(2):93-9.
Resistant starch (RS) includes the sum of starch and degradation products of starch that resist small intestinal digestion and enter the colon. This study was planned to examine the effect of resistant starch on hypolipidemic actions, blood glucose, insulin levels and humoral immune responses in healthy overweight subjects. Healthy overweight subjects (over 120% of their ideal body weights) were fed either 24 g/d of resistant corn starch (RS) or regular corn starch (CS) for 21 d with their regular meals. Although this double-blind feeding regiment resulted in no significant changes in their weights or other physical parameters for the relatively acute period of intakes, there were significant lowering effects of serum total cholesterol (p < 0.05) and serum LDL-cholesterol (p < 0.05) in subjects supplemented RS. Compared with the control starch group, the RS supplementation also reduced the mean fasting serum glucose concentrations (p < 0.05). Resistant starch supplement resulted in the increase in serum immunoglobulin G (IgG) concentrations. Serum insulin and complement 3 (C3) were unaffected. Tested resistant starch supplementation was reported to be palatable with minimal bowel discomfort. These results suggest that RS supplementation improves the blood lipid profile and controls the blood glucose levels in healthy overweight subjects without bowel discomfort. Therefore, RS has a potential to be used as one of the promising food ingredients for reducing risk factors involved in the development of atherosclerosis and type 2 diabetes in overweight individuals. However, in order to prove RS as a novel therapeutic agent of cardiovascular diseases and diabetes, controlled trials with larger sample sizes and longer duration are warranted.
抗性淀粉（RS）包括抵抗小肠消化并进入结肠的淀粉及其降解产物的总和。本研究旨在探讨抗性淀粉对健康超重受试者的降血脂作用、血糖、胰岛素水平及体液免疫反应的影响。健康超重受试者（体重超过理想体重的120%）在正常饮食的基础上，连续21天每天摄入24克抗性玉米淀粉（RS）或普通玉米淀粉（CS）。尽管这种双盲喂养方案在相对较短的摄入期内对他们的体重或其他身体参数没有显著影响，但补充RS的受试者血清总胆固醇（p<0.05）和血清低密度脂蛋白胆固醇（p<0.05）有显著降低作用。与对照淀粉组相比，补充RS还降低了空腹血清葡萄糖的平均浓度（p<0.05）。补充抗性淀粉导致血清免疫球蛋白G（IgG）浓度升高。血清胰岛素和补体3（C3）未受影响。据报道，测试的抗性淀粉补充剂口感良好，肠道不适最小。这些结果表明，补充RS可改善健康超重受试者的血脂状况并控制血糖水平，且无肠道不适。因此，RS有潜力作为一种有前景的食品成分，用于降低超重个体发生动脉粥样硬化和2型糖尿病的风险因素。然而，为了证明RS是心血管疾病和糖尿病的新型治疗剂，有必要进行更大样本量和更长时间的对照试验。
