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华支睾吸虫重组7千道尔顿抗原用于华支睾吸虫病血清学诊断的评估

Evaluation of Clonorchis sinensis recombinant 7-kilodalton antigen for serodiagnosis of clonorchiasis.

作者信息

Zhao Qin-Ping, Moon Sung-Ung, Lee Hyeong-Woo, Na Byoung-Kuk, Cho Seung-Yull, Kong Yoon, Jiang Ming-Sen, Li Ai-Hua, Kim Tong-Soo

机构信息

Department of Tropical and Endemic Parasitic Diseases, National Institute of Health, Seoul 122-701, Korea.

出版信息

Clin Diagn Lab Immunol. 2004 Jul;11(4):814-7. doi: 10.1128/CDLI.11.4.814-817.2004.

Abstract

The diagnostic applicability of the Clonorchis sinensis recombinant 7-kDa protein was evaluated. In enzyme-linked immunosorbent assays and immunoblots, the protein showed high sensitivities (81.3 and 71.9%, respectively) and specificities (92.6 and 89.7%, respectively) for sera obtained from various helminthic infections. Some paragonimiasis sera showed cross-reactions. The antigen might be valuable in the serodiagnosis of human clonorchiasis.

摘要

评估了华支睾吸虫重组7-kDa蛋白的诊断适用性。在酶联免疫吸附测定和免疫印迹中,该蛋白对从各种蠕虫感染获得的血清显示出高敏感性(分别为81.3%和71.9%)和特异性(分别为92.6%和89.7%)。一些肺吸虫病血清显示出交叉反应。该抗原可能在人类华支睾吸虫病的血清诊断中有价值。

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