胃食管反流症状患者食管外反流的患病率。
Prevalence of extraesophageal reflux in patients with symptoms of gastroesophageal reflux.
作者信息
Ylitalo Riitta, Ramel Stig, Hammarlund Birgitta, Lindgren Elisabeth
机构信息
Huddinge University Hospital, Stockholm, Sweden.
出版信息
Otolaryngol Head Neck Surg. 2004 Jul;131(1):29-33. doi: 10.1016/j.otohns.2004.02.021.
OBJECTIVES
To compare the prevalence of extraesophageal reflux (EER) in patients with heartburn, posterior laryngitis (PL), and in healthy controls. Study design and setting A retrospective and prospective study including a total of 101 subjects who underwent 24-hour dual-probe pH monitoring.
RESULTS
52% of the subjects with heartburn had EER. No significant differences were found between the PL and heartburn groups for any pharyngeal reflux parameters. However, supine pharyngeal reflux was significantly more prevalent in heartburn patients with GERD than in PL patients and healthy controls (P < 0.05). Significant positive correlation (P < 0.01) was found between the percentage of time pH <4 in the pharynx and in the distal esophagus.
CONCLUSION
EER occurs in the majority of heartburn patients who are lacking laryngeal symptoms. Abnormal distal esophageal acid exposure makes the occurrence of EER more likely.
SIGNIFICANCE
EER appears to be a continuum without clear-cut differences between the groups.
目的
比较烧心患者、喉后部炎症（PL）患者及健康对照者食管外反流（EER）的患病率。研究设计与背景 一项回顾性和前瞻性研究，共纳入101例接受24小时双探头pH监测的受试者。
结果
52%的烧心患者存在EER。在PL组和烧心组之间，任何咽部反流参数均未发现显著差异。然而，GERD烧心患者的仰卧位咽部反流明显比PL患者和健康对照者更常见（P<0.05）。咽部和食管远端pH<4的时间百分比之间存在显著正相关（P<0.01）。
结论
大多数无喉部症状的烧心患者存在EER。食管远端异常酸暴露使EER更易发生。
意义
EER似乎是一个连续过程，各组之间无明显差异。
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