Goh Victor H H, Tain C F, Tong Terry Y Y, Mok Helen P P, Wong M T
Department of Obstetrics and Gynecology, National University of Singapore, National University Hospital, Kent Ridge, Singapore 119074.
J Lipid Res. 2004 Oct;45(10):1892-8. doi: 10.1194/jlr.M400159-JLR200. Epub 2004 Jul 16.
We have examined the relationships between percentage of body fat (PBF) and risk factors for cardiovascular disease and insulin resistance and how good body mass index (BMI) and other anthropometric measures are as indices of obesity. High PBF levels were associated with increased risk of cardiovascular disease and insulin resistance. The World Health Organization BMI of 30 kg/m(2) for obesity has low sensitivity, 6.7% and 13.4% for men and women, respectively. For every obese man and woman identified, 6.7 and 1.76 times nonobese men and women, respectively, will be misclassified as obese. With the locally established BMI cutoff point for obesity of 27 kg/m(2) for men and 25 kg/m(2) for women, the sensitivity was improved to 46.7% and 60.8%, respectively. For every obese man and woman identified, 3.76 and 1.64 times nonobese men and women, respectively, will be misclassified as obese. None of the other anthropometric indices was better than the locally established BMIs. We showed that the BMIs for obesity for our local men and women are different. These BMIs were most precise among all indices studied. However, they still lead to high false-positive rates. For more effective management of the problem of obesity, we need to develop more precise, simple, and cost-effective methods for the measurement of PBF.
我们研究了体脂百分比（PBF）与心血管疾病风险因素及胰岛素抵抗之间的关系，以及体重指数（BMI）和其他人体测量指标作为肥胖指标的有效性。高PBF水平与心血管疾病风险增加及胰岛素抵抗相关。世界卫生组织将肥胖的BMI定义为30 kg/m²，其敏感性较低，男性和女性分别为6.7%和13.4%。每识别出一名肥胖男性和女性，分别会有6.7倍和1.76倍的非肥胖男性和女性被误分类为肥胖。对于本地确定的男性肥胖BMI切点为27 kg/m²、女性为25 kg/m²时，敏感性分别提高到了46.7%和60.8%。每识别出一名肥胖男性和女性，分别会有3.76倍和1.64倍的非肥胖男性和女性被误分类为肥胖。其他人体测量指标均不比本地确定的BMI更好。我们发现本地男性和女性的肥胖BMI不同。这些BMI在所有研究指标中最为精确。然而，它们仍会导致较高的假阳性率。为了更有效地管理肥胖问题，我们需要开发更精确、简单且经济高效的PBF测量方法。
