Chen Chien-Lin, Lin Hsien-Hong, Huang Lu-Chin, Huang Shih-Che, Liu Tso-Tsai
Department of Medicine, Buddhist Tzu Chi General Hospital and University School of Medicine, Hualien 970, Taiwan.
Dig Dis Sci. 2004 May;49(5):715-9. doi: 10.1023/b:ddas.0000030079.20501.62.
Many patients with gastroesophgeal reflux disease (GERD) may also have overlapping symptoms of dyspepsia. This study was to examine if GERD patients could be separated into meaningful groups based on their gastric myoelectrical characteristics. The study included 20 GERD patients with dyspeptc symptoms (GERD+) and 17 patients with GERD. Gastric myoelectrical activity was assessed using cutaneous electrodes to record electrogastrograms (EGGs). The GERD+ patients ingested smaller volumes of water compared to patients with GERD (P < 0.05). At baseline, the percentage of gastric myoelectrical power in the normal 3-cpm range was significantly less in patients with GERD+ compared with the GERD subjects (P = 0.01). Power in the bradygastria range was significantly greater in patients with GERD+ (P = 0.005). The GERD+ group had a significant increase in the percentage of power in the tachygastria range later after ingesting the water load (P < 0.01). In conclusion, this study has shown that more gastric dysrhythmias were detected in the GERD+ patients accompanied with altered perception of stomach fullness.
许多胃食管反流病（GERD）患者可能还伴有消化不良的重叠症状。本研究旨在探讨GERD患者是否可根据其胃肌电特征分为有意义的组。该研究纳入了20例有消化不良症状的GERD患者（GERD+）和17例GERD患者。使用皮肤电极记录胃电图（EGG）来评估胃肌电活动。与GERD患者相比，GERD+患者摄入的水量较少（P<0.05）。在基线时，GERD+患者正常3次/分钟范围内的胃肌电功率百分比显著低于GERD患者（P = 0.01）。GERD+患者胃动过缓范围内的功率显著更高（P = 0.005）。GERD+组在摄入水负荷后，心动过速范围内的功率百分比显著增加（P<0.01）。总之，本研究表明，GERD+患者伴有胃饱胀感改变时，检测到更多的胃节律紊乱。
