Iannaccone A, Letizia C, Pazzaglia S, Vingolo E M, Clemente G, Pannarale M R
Institute of Ophthalmology, University La Sapienza, Rome, Italy.
Br J Ophthalmol. 1998 May;82(5):498-503. doi: 10.1136/bjo.82.5.498.
To investigate whether plasma levels of endothelin-1 (ET-1), a potent vasoconstricting peptide that is crucial in regulating retinal blood flow, were elevated in patients with retinal vein occlusion (RVO).
ET-1 plasma concentrations were determined by radioimmunoassays in a double blind fashion in a group of 18 selected patients with RVO, in 20 healthy age matched non-smoking, normoglycaemic, normotensive control subjects, and in 15 patients with uncomplicated essential hypertension in the same age range.
Patients with RVO had significantly increased ET-1 plasma levels (14.22 (SD 4.6) pg/ml) compared with both normal subjects (7.90 (1.6) pg/ml; p < 0.05) and hypertensive patients (8.50 (2.9) pg/ml; p < 0.05). The highest concentrations of circulating ET-1 were found in patients with RVO of the ischaemic type (16.97 (3.5) pg/ml; p < 0.01; n = 7). Systemic hypertension alone did not account for the observed increase in plasma ET-1 concentrations.
These findings raise the possibility that the increased circulating ET-1 levels in patients with RVO may be a marker of the occlusive event, thereby suggesting that ET-1 homeostasis may be relevant to RVO pathogenesis and retinal ischaemic manifestations.
研究视网膜静脉阻塞（RVO）患者血浆中内皮素-1（ET-1）水平是否升高，ET-1是一种强效血管收缩肽，对调节视网膜血流至关重要。
采用放射免疫分析法以双盲方式测定18例入选的RVO患者、20例年龄匹配的健康非吸烟、血糖正常、血压正常的对照者以及15例年龄范围相同的单纯原发性高血压患者的ET-1血浆浓度。
与正常受试者（7.90（标准差1.6）pg/ml；p<0.05）和高血压患者（8.50（2.9）pg/ml；p<0.05）相比，RVO患者的ET-1血浆水平显著升高（14.22（标准差4.6）pg/ml）。缺血型RVO患者的循环ET-1浓度最高（16.97（3.5）pg/ml；p<0.01；n=7）。单纯系统性高血压并不能解释观察到的血浆ET-1浓度升高。
这些发现提示，RVO患者循环ET-1水平升高可能是阻塞事件的一个标志物，从而表明ET-1内稳态可能与RVO发病机制和视网膜缺血表现有关。
