比较基因组学：纤毛和基体蛋白质组的预测

Comparative genomics: prediction of the ciliary and basal body proteome.

作者信息

Pazour Gregory J

机构信息

Program in Molecular Medicine, University of Massachusetts Medical School, Biotech II, Suite 213, 373 Plantation St., Worcester, Massachusetts 01605, USA.

出版信息

Curr Biol. 2004 Jul 27;14(14):R575-7. doi: 10.1016/j.cub.2004.07.017.

DOI:10.1016/j.cub.2004.07.017

PMID:15268880

Abstract

Defects in mammalian cilia lead to a range of diseases, but our understanding of the composition of these organelles and of the basal bodies from which they arise is limited. Two recent studies used comparative genomics to predict the ciliary and basal body proteomes, providing datasets that are rich sources of human disease gene candidates.

摘要

哺乳动物纤毛的缺陷会导致一系列疾病，但我们对这些细胞器及其起源的基体的组成了解有限。最近的两项研究利用比较基因组学来预测纤毛和基体蛋白质组，提供了丰富的人类疾病基因候选来源数据集。