原发性纤毛在骨细胞中作为机械感受器的作用日益显现。
Emerging role of primary cilia as mechanosensors in osteocytes.
机构信息
Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA.
出版信息
Bone. 2013 Jun;54(2):196-204. doi: 10.1016/j.bone.2012.11.016. Epub 2012 Nov 28.
Abstract
The primary cilium is a solitary, immotile microtubule-based extension present on nearly every mammalian cell. This organelle has established mechanosensory roles in several contexts including kidney, liver, and the embryonic node. Mechanical load deflects the cilium, triggering biochemical responses. Defects in cilium function have been associated with numerous human diseases. Recent research has implicated the primary cilium as a mechanosensor in bone. In this review, we discuss the cilium, the growing evidence for its mechanosensory role in bone, and areas of future study.
摘要
初级纤毛是一种存在于几乎每一个哺乳动物细胞上的、单一的、无动力的微管延伸结构。该细胞器在多种环境中都具有机械感受器的作用，包括肾脏、肝脏和胚胎节点。机械负荷会使纤毛弯曲，从而引发生化反应。纤毛功能缺陷与许多人类疾病有关。最近的研究表明，初级纤毛是骨骼中的一种机械感受器。在这篇综述中，我们讨论了纤毛，其在骨骼中机械感受器作用的不断增加的证据，以及未来的研究领域。
相似文献
1
Emerging role of primary cilia as mechanosensors in osteocytes.原发性纤毛在骨细胞中作为机械感受器的作用日益显现。
Bone. 2013 Jun;54(2):196-204. doi: 10.1016/j.bone.2012.11.016. Epub 2012 Nov 28.
2
Osteocyte primary cilium and its role in bone mechanotransduction.成骨细胞原纤毛及其在骨机械转导中的作用。
Ann N Y Acad Sci. 2010 Mar;1192:422-8. doi: 10.1111/j.1749-6632.2009.05243.x.
3
The solitary (primary) cilium--a mechanosensory toggle switch in bone and cartilage cells.单个（初级）纤毛——骨细胞和软骨细胞中的一种机械感觉切换开关。
Cell Signal. 2008 Jun;20(6):1019-24. doi: 10.1016/j.cellsig.2007.12.001. Epub 2007 Dec 8.
4
Osteocytes and Primary Cilia.骨细胞和初级纤毛。
Curr Osteoporos Rep. 2023 Dec;21(6):719-730. doi: 10.1007/s11914-023-00819-1. Epub 2023 Sep 8.
5
Primary cilia: Cell and molecular mechanosensors directing whole tissue function.初级纤毛：指导整个组织功能的细胞和分子机械感受器。
Semin Cell Dev Biol. 2017 Nov;71:42-52. doi: 10.1016/j.semcdb.2017.08.036. Epub 2017 Aug 24.
6
Adenylyl cyclase 3 regulates osteocyte mechanotransduction and primary cilium.腺苷酸环化酶 3 调节骨细胞机械转导和初级纤毛。
Biochem Biophys Res Commun. 2021 Oct 8;573:145-150. doi: 10.1016/j.bbrc.2021.08.033. Epub 2021 Aug 12.
7
Primary cilia: cellular sensors for the skeleton.初级纤毛：骨骼的细胞传感器。
Anat Rec (Hoboken). 2008 Sep;291(9):1074-8. doi: 10.1002/ar.20754.
8
Pharmacological Regulation of Primary Cilium Formation Affects the Mechanosensitivity of Osteocytes.药物调节初级纤毛的形成会影响骨细胞的机械敏感性。
Calcif Tissue Int. 2020 Dec;107(6):625-635. doi: 10.1007/s00223-020-00756-6. Epub 2020 Sep 17.
9
The mechanics of the primary cilium: an intricate structure with complex function.原发性纤毛的力学机制：一种具有复杂功能的复杂结构。
J Biomech. 2012 Jan 3;45(1):17-26. doi: 10.1016/j.jbiomech.2011.08.008. Epub 2011 Sep 6.
10
PTH1R translocation to primary cilia in mechanically-stimulated ostecytes prevents osteoclast formation via regulation of CXCL5 and IL-6 secretion.机械刺激破骨细胞中 PTH1R 向初级纤毛的易位通过调节 CXCL5 和 IL-6 分泌来防止破骨细胞的形成。
J Cell Physiol. 2022 Oct;237(10):3927-3943. doi: 10.1002/jcp.30849. Epub 2022 Aug 7.
引用本文的文献
1
Shear stress effects on epididymal epithelial cell via primary cilia mechanosensory signaling.剪切应力通过初级纤毛机械感受信号传导对附睾上皮细胞产生影响。
J Cell Physiol. 2025 Jan;240(1):e31475. doi: 10.1002/jcp.31475. Epub 2024 Nov 7.
2
A 3-Dimensional Scaffolding System Recapitulates the Hierarchical Osteon Structure.一种三维支架系统重现了分层骨单位结构。
ACS Omega. 2024 Sep 24;9(40):41368-41377. doi: 10.1021/acsomega.4c04146. eCollection 2024 Oct 8.
3
Brain regulates weight bearing bone through PGE2 skeletal interoception: implication of ankle osteoarthritis and pain.大脑通过 PGE2 骨骼本体感觉调节承重骨骼：踝关节骨关节炎和疼痛的意义。
Bone Res. 2024 Mar 5;12(1):16. doi: 10.1038/s41413-024-00316-w.
4
Osteocytes and Primary Cilia.骨细胞和初级纤毛。
Curr Osteoporos Rep. 2023 Dec;21(6):719-730. doi: 10.1007/s11914-023-00819-1. Epub 2023 Sep 8.
5
Osteoclastogenesis Requires Primary Cilia Disassembly and Can Be Inhibited by Promoting Primary Cilia Formation Pharmacologically.破骨细胞的形成需要初级纤毛解体，并且可以通过促进初级纤毛的形成来抑制。
Cells Tissues Organs. 2024;213(3):235-244. doi: 10.1159/000531098. Epub 2023 May 22.
6
Study on the influence of scaffold morphology and structure on osteogenic performance.支架形态和结构对成骨性能的影响研究
Front Bioeng Biotechnol. 2023 Mar 27;11:1127162. doi: 10.3389/fbioe.2023.1127162. eCollection 2023.
7
Zebrafish crocc2 mutants exhibit divergent craniofacial shape, misregulated variability, and aberrant cartilage morphogenesis.斑马鱼 crocc2 突变体表现出不同的颅面形状、调节异常的可变性和异常的软骨形态发生。
Dev Dyn. 2023 Jul;252(7):1026-1045. doi: 10.1002/dvdy.591. Epub 2023 Apr 18.
8
Identification of a heterogeneous and dynamic ciliome during embryonic development and cell differentiation.鉴定胚胎发育和细胞分化过程中的异质和动态纤毛组。
Development. 2023 Apr 15;150(8). doi: 10.1242/dev.201237. Epub 2023 Apr 27.
9
Characterization of Primary Cilia Formation in Human ESC-Derived Retinal Organoids.人胚胎干细胞来源的视网膜类器官中初级纤毛形成的特征分析。
Stem Cells Int. 2023 Jan 13;2023:6494486. doi: 10.1155/2023/6494486. eCollection 2023.
10
Role of mechano-sensitive non-coding RNAs in bone remodeling of orthodontic tooth movement: recent advances.力学敏感性非编码 RNA 在正畸牙齿移动中的骨重塑作用：最新进展。
Prog Orthod. 2022 Dec 30;23(1):55. doi: 10.1186/s40510-022-00450-3.
本文引用的文献
1
Adenylyl cyclase 6 mediates loading-induced bone adaptation in vivo.腺苷酸环化酶 6 介导体内负荷诱导的骨适应。
FASEB J. 2014 Mar;28(3):1157-65. doi: 10.1096/fj.13-240432. Epub 2013 Nov 25.
2
Primary cilia act as mechanosensors during bone healing around an implant.初级纤毛在植入物周围骨愈合过程中充当机械感受器。
Med Eng Phys. 2013 Mar;35(3):392-402. doi: 10.1016/j.medengphy.2012.06.005. Epub 2012 Jul 10.
3
Chondrocyte primary cilia shorten in response to osmotic challenge and are sites for endocytosis.软骨细胞初级纤毛在渗透挑战下缩短，并且是内吞作用的部位。
Osteoarthritis Cartilage. 2012 Aug;20(8):923-30. doi: 10.1016/j.joca.2012.04.017. Epub 2012 Apr 30.
4
Mainzer-Saldino syndrome is a ciliopathy caused by IFT140 mutations.梅因策尔-萨尔迪诺综合征是一种由 IFT140 突变引起的纤毛病。
Am J Hum Genet. 2012 May 4;90(5):864-70. doi: 10.1016/j.ajhg.2012.03.006. Epub 2012 Apr 12.
5
An experimental and computational analysis of primary cilia deflection under fluid flow.流体流动下初级纤毛偏转的实验与计算分析
Comput Methods Biomech Biomed Engin. 2014;17(1):2-10. doi: 10.1080/10255842.2011.653784. Epub 2012 Mar 28.
6
Mechanosensing by the primary cilium: deletion of Kif3A reduces bone formation due to loading.原发性纤毛的机械感应：Kif3A 的缺失会减少因负荷引起的骨形成。
PLoS One. 2012;7(3):e33368. doi: 10.1371/journal.pone.0033368. Epub 2012 Mar 12.
7
Disruption of Kif3a in osteoblasts results in defective bone formation and osteopenia.破骨细胞中 Kif3a 的缺失导致骨形成缺陷和骨质疏松症。
J Cell Sci. 2012 Apr 15;125(Pt 8):1945-57. doi: 10.1242/jcs.095893. Epub 2012 Feb 22.
8
Proteomic analysis of mammalian primary cilia.哺乳动物初级纤毛的蛋白质组学分析。
Curr Biol. 2012 Mar 6;22(5):414-9. doi: 10.1016/j.cub.2012.01.031. Epub 2012 Feb 9.
9
Downregulation of PKD1 by shRNA results in defective osteogenic differentiation via cAMP/PKA pathway in human MG-63 cells.短发夹 RNA 下调 PKD1 通过 cAMP/PKA 通路导致人 MG-63 细胞成骨分化缺陷。
J Cell Biochem. 2012 Mar;113(3):967-76. doi: 10.1002/jcb.23426.
10
The mechanics of the primary cilium: an intricate structure with complex function.原发性纤毛的力学机制：一种具有复杂功能的复杂结构。
J Biomech. 2012 Jan 3;45(1):17-26. doi: 10.1016/j.jbiomech.2011.08.008. Epub 2011 Sep 6.
Zotero 插件