对于伯氏疏螺旋体在蜱虫中的定殖、传播至哺乳动物宿主或引发疾病而言，luxS基因并非必需。
The luxS gene is not required for Borrelia burgdorferi tick colonization, transmission to a mammalian host, or induction of disease.
作者信息
Blevins Jon S, Revel Andrew T, Caimano Melissa J, Yang Xiaofeng F, Richardson James A, Hagman Kayla E, Norgard Michael V
机构信息
Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, 75390, USA.
出版信息
Infect Immun. 2004 Aug;72(8):4864-7. doi: 10.1128/IAI.72.8.4864-4867.2004.
Abstract
luxS mutants of Borrelia burgdorferi strain 297 naturally colonized their arthropod (Ixodes scapularis) vector, were maintained in ticks throughout the molting process (larvae to nymphs), were tick transmitted to uninfected mice, and elicited histopathology in mice indistinguishable from that induced by wild-type B. burgdorferi.
摘要
伯氏疏螺旋体菌株297的luxS突变体自然定殖于其节肢动物（肩突硬蜱）载体中，在整个蜕皮过程（幼虫到若虫）中在蜱虫体内维持存活，通过蜱虫传播给未感染的小鼠，并在小鼠中引发与野生型伯氏疏螺旋体诱导的组织病理学无法区分的病变。
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