Miller Christopher J, Ioffreda Michael D, Ammirati Christie T
Resident in Dermatology, Department of Dermatology, Penn State Milton S.Hershey Medical Centre/Penn State College of Medicine, Hershey, Pennsylvania 17033-0850, USA.
Dermatol Surg. 2004 Aug;30(8):1169-73. doi: 10.1111/j.1524-4725.2004.30349.x.
Angiolymphoid hyperplasia with eosinophilia is a benign vascular proliferation that typically presents on the head and neck. Multiple treatment modalities have been proposed for angiolymphoid hyperplasia with eosinophilia, each with limited success or undesirable side effects. At this time, standard surgical excision is considered the treatment of choice but carries recurrence rates of 33% to 50%.
The objective was to present a case of angiolymphoid hyperplasia with eosinophilia successfully extirpated using Mohs micrographic surgery.
A 52-year-old woman presented with an ill-defined solitary plaque of angiolymphoid hyperplasia with eosinophilia within her left conchal bowl that enlarged despite conservative therapy with intralesional and topical corticosteroids. Mohs micrographic surgery using the fresh tissue technique and standard hematoxylin and eosin staining was performed. The characteristic histologic features of angiolymphoid hyperplasia with eosinophilia were readily identifiable on frozen sections and complete extirpation required two stages of micrographically controlled resection.
Resection of angiolymphoid hyperplasia with eosinophilia of the conchal bowl with complete resolution of symptoms and no evidence of clinical recurrence 8 months after surgery.
Given the high recurrence rates reported for standard excision, Mohs micrographic surgery with complete margin examination should be considered as a treatment option for angiolymphoid hyperplasia with eosinophilia, particularly for lesions with ill-defined margins or in locations where tissue sparing is desirable.
嗜酸性粒细胞增多性血管淋巴样增生是一种良性血管增生,通常出现在头颈部。针对嗜酸性粒细胞增多性血管淋巴样增生,已提出多种治疗方式,但每种方式的成功率有限或存在不良副作用。目前,标准手术切除被认为是首选治疗方法,但复发率为33%至50%。
介绍一例通过莫氏显微描记手术成功切除嗜酸性粒细胞增多性血管淋巴样增生的病例。
一名52岁女性患者,其左侧耳甲腔内出现边界不清的孤立性嗜酸性粒细胞增多性血管淋巴样增生斑块,尽管采用病灶内和局部皮质类固醇进行保守治疗,该斑块仍不断增大。采用新鲜组织技术及标准苏木精-伊红染色进行莫氏显微描记手术。嗜酸性粒细胞增多性血管淋巴样增生的典型组织学特征在冰冻切片上易于识别,完整切除需要两个阶段的显微控制切除。
切除耳甲腔嗜酸性粒细胞增多性血管淋巴样增生后,症状完全缓解,术后8个月无临床复发迹象。
鉴于标准切除术后报道的高复发率,对于嗜酸性粒细胞增多性血管淋巴样增生,应考虑采用能进行完整切缘检查的莫氏显微描记手术作为一种治疗选择,特别是对于边界不清的病变或需要保留组织的部位。