Zhao Yulian, Vlahos Nikos, Wyncott David, Petrella Carolina, Garcia Jairo, Zacur Howard, Wallach Edward E
Department of Ob/Gyn, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
J Assist Reprod Genet. 2004 May;21(5):143-8. doi: 10.1023/b:jarg.0000031246.76666.f6.
To evaluate the influence of sperm characteristics on the outcome of infertility treatment using intrauterine insemination (IUI).
Retrospective study of 431 infertility couples who underwent 1007 IUI treatment cycles from June 1999 to October 2002. Sperm parameters before and after preparation for IUI were evaluated and correlated with pregnancy outcome.
Clinical pregnancy occurred in 12% of cycles and 28% of patients. Initial sperm motility and processed forward progression were independently associated with pregnancy after IUI. The mean number of cycles per patient was 4.3. Although pregnancy rate per cycle did not differ from cycle to cycle, the cumulative pregnancy rate approached plateau after five cycles.
Sperm motility is an independent factor influencing IUI-related pregnancy. A forward progression score of 3 to 4 in a processed specimen is necessary for IUI success. The number of IUI attempts per patient should be individualized depending upon the needs of patients.
评估精子特征对宫腔内人工授精(IUI)治疗不孕症结局的影响。
对1999年6月至2002年10月期间接受1007个IUI治疗周期的431对不孕夫妇进行回顾性研究。评估IUI准备前后的精子参数,并将其与妊娠结局相关联。
12%的周期和28%的患者发生临床妊娠。IUI后,初始精子活力和处理后的前向运动与妊娠独立相关。每位患者的平均周期数为4.3个。尽管每个周期的妊娠率在各周期之间没有差异,但累积妊娠率在五个周期后接近平稳。
精子活力是影响IUI相关妊娠的独立因素。处理后的样本前向运动评分为3至4分是IUI成功的必要条件。每位患者的IUI尝试次数应根据患者需求个体化。