Mateos-Timoneda Miguel A, Crego-Calama Mercedes, Reinhoudt David N
Laboratory of Supramolecular Chemistry and Technology, MESA+ Research Institute, University of Twente, P. O. Box 217, 7500 AE Enschede, The Netherlands.
Chem Soc Rev. 2004 Jul 30;33(6):363-72. doi: 10.1039/b305550g. Epub 2004 Jul 6.
Self-assembly plays an important role in the formation of many (chiral) biological structures, such as DNA, alpha-helices or beta-sheets of proteins. This process, which is the main tool of Supramolecular Chemistry (i.e. the chemistry of the molecular assemblies and of the intermolecular bonds), starts to play a significant role in nanotechnology for the construction of functional synthetic structures of nanometer size. The control of chirality in synthetic self-assembled systems is very important for applications of these systems e.g. in molecular recognition or mimicking of the catalytic activity of enzymes. This tutorial review deals with the most representative contributions in the field of supramolecular chirality. Specifically, the discussion centers on several examples that represent the control over chirality for self-assembled systems in solution.
自组装在许多（手性）生物结构的形成过程中起着重要作用，如DNA、蛋白质的α-螺旋或β-折叠。这个过程是超分子化学（即分子组装和分子间键合的化学）的主要手段，在纳米技术中，对于构建纳米尺寸的功能性合成结构开始发挥重要作用。在合成自组装体系中控制手性对于这些体系的应用非常重要，例如在分子识别或模拟酶的催化活性方面。本综述性教程探讨了超分子手性领域最具代表性的研究成果。具体而言，讨论集中在几个代表溶液中自组装体系手性控制的例子上。
