Gottarelli Giovanni, Lena Stefano, Masiero Stefano, Pieraccini Silvia, Spada Gian Piero
Alma Mater Studiorum - Università di Bologna, Dipartimento di Chimica Organica A. Mangini, via San Giacomo 11, Bologna, Italy.
Chirality. 2008 Mar;20(3-4):471-85. doi: 10.1002/chir.20459.
Self-assembly plays an important role in the formation of many chiral biological structures and in the preparation of chiral functional materials. Therefore the control of chirality in synthetic or biological self-assembled systems is important either for the comprehension of recognition phenomena or to obtain materials with predictable and controllable properties. Circular dichroism was developed to study molecular chirality, however, because of its outstanding sensitivity to chiral perturbations of the system under investigation; it has been extended more recently to supramolecular chemistry. In particular, self-assembly processes leading to the formation of chiral supramolecular architectures (and eventually to gels or liquid crystal phases) can be monitored by CD. Furthermore, CD spectroscopy often allows one to obtain structural information on the assembled structures. This review deals with representative contributions to the study of supramolecular chirality by means of circular dichroism.
自组装在许多手性生物结构的形成以及手性功能材料的制备过程中发挥着重要作用。因此，对于理解识别现象或获得具有可预测和可控性质的材料而言，控制合成或生物自组装体系中的手性至关重要。圆二色性最初是为研究分子手性而开发的，然而，由于其对所研究体系的手性微扰具有出色的灵敏度，近年来已扩展至超分子化学领域。特别是，通过圆二色性可以监测导致手性超分子结构（最终形成凝胶或液晶相）形成的自组装过程。此外，圆二色光谱通常能使人们获得有关组装结构的结构信息。本综述论述了借助圆二色性对超分子手性研究的代表性贡献。
