Quesniaux Valerie, Fremond Cecile, Jacobs Muazzam, Parida Shreemanta, Nicolle Delphine, Yeremeev Vladimir, Bihl Franck, Erard Francois, Botha Tania, Drennan Michael, Soler Marie-Noelle, Le Bert Marc, Schnyder Bruno, Ryffel Bernhard
CNRS, IEM2815, Institut Transgenose, 3B, rue de la Ferollerie, 45071 Orleans, France.
Microbes Infect. 2004 Aug;6(10):946-59. doi: 10.1016/j.micinf.2004.04.016.
The control of Mycobacterium tuberculosis infection depends on recognition of the pathogen and the activation of both the innate and adaptive immune responses. Toll-like receptors (TLR) were shown to play a critical role in the recognition of several pathogens. Mycobacterial antigens recognise distinct TLR resulting in rapid activation of cells of the innate immune system. Recent evidence from in vitro and in vivo investigations, summarised in this review demonstrates TLR-dependent activation of innate immune response, while the induction of adaptive immunity to mycobacteria may be TLR independent.
结核分枝杆菌感染的控制取决于对病原体的识别以及固有免疫和适应性免疫反应的激活。Toll样受体（TLR）已被证明在识别多种病原体中起关键作用。分枝杆菌抗原可识别不同的TLR，从而导致固有免疫系统细胞的快速激活。本综述总结的近期体外和体内研究证据表明，固有免疫反应的激活依赖于TLR，而对分枝杆菌适应性免疫的诱导可能与TLR无关。
