Kohli Punit, Harrell C Chad, Cao Zehui, Gasparac Rahela, Tan Weihong, Martin Charles R
Department of Chemistry and Center for Research at the Bio/Nano Interface, University of Florida, Gainesville, FL 32611-7200, USA.
Science. 2004 Aug 13;305(5686):984-6. doi: 10.1126/science.1100024.
We describe synthetic membranes in which the molecular recognition chemistry used to accomplish selective permeation is DNA hybridization. These membranes contain template-synthesized gold nanotubes with inside diameters of 12 nanometers, and a "transporter" DNA-hairpin molecule is attached to the inside walls of these nanotubes. These DNA-functionalized nanotube membranes selectively recognize and transport the DNA strand that is complementary to the transporter strand, relative to DNA strands that are not complementary to the transporter. Under optimal conditions, single-base mismatch transport selectivity can be obtained.
我们描述了一种合成膜，其中用于实现选择性渗透的分子识别化学过程是DNA杂交。这些膜包含内径为12纳米的模板合成金纳米管，并且一种“转运体”DNA发夹分子附着在这些纳米管的内壁上。相对于与转运体链不互补的DNA链，这些DNA功能化的纳米管膜能够选择性地识别并转运与转运体链互补的DNA链。在最佳条件下，可以获得单碱基错配的转运选择性。
