He Xiao-Jie, Han Chun-Mao
Department of Burns, The Second Affiliated Hospital of School of Medicine, Zhejiang University, Hangzhou 310009, P. R. China.
Zhonghua Shao Shang Za Zhi. 2004 Apr;20(2):79-81.
To investigate the expression of tenascin-C (Tn-C) in keloid and hyperplastic scar (HS).
Tissue samples were harvested from 10 patients with keloid and 10 with HS (6 - 10 months) and from the skin of 5 adult healthy volunteers. The expression of Tn-C in these samples was determined with immunohistochemistry method.
There was scarce expression of Tn-C in the skin tissue in adult healthy volunteers, and it was only present in the dermal papillae at the dermis epidermis conjunctions and partly in the blood vessels and skin appendages adjacent to the basement membrane. There was enhanced expression of Tn-C in the dermal scar tissue and skin appendages in both keloid and HS, especially in keloid, which exhibited a diffused pattern in the tissue. When compared with that in normal skin, the Tn-C expression in the normal skin adjacent to the keloid was enhanced markedly, but not in the normal skin near HS tissue.
There was increased Tn-C expression in keloid and HS (6 - 10 months).
研究肌腱蛋白-C（Tn-C）在瘢痕疙瘩和增生性瘢痕（HS）中的表达情况。
从10例瘢痕疙瘩患者、10例增生性瘢痕患者（病程6 - 10个月）以及5名成年健康志愿者的皮肤中采集组织样本。采用免疫组织化学方法测定这些样本中Tn-C的表达。
成年健康志愿者皮肤组织中Tn-C表达稀少，仅存在于真皮表皮连接处的真皮乳头以及部分紧邻基底膜的血管和皮肤附属器中。在瘢痕疙瘩和增生性瘢痕的真皮瘢痕组织及皮肤附属器中，Tn-C表达增强，尤其是在瘢痕疙瘩中，其在组织中呈弥漫性分布。与正常皮肤相比，瘢痕疙瘩旁正常皮肤中的Tn-C表达明显增强，但增生性瘢痕组织旁正常皮肤中的Tn-C表达未增强。
瘢痕疙瘩和增生性瘢痕（病程6 - 10个月）中Tn-C表达增加。
