Miyata Akira, Yaguchi Shigeo
Miyata Eye Clinic, 2-23-32 Inokuchidai Nishi-ku, Hiroshima-shi, Hiroshima, Japan.
J Cataract Refract Surg. 2004 Aug;30(8):1768-72. doi: 10.1016/j.jcrs.2003.12.038.
To investigate the possible relationship between temperature and water absorption in acrylic intraocular lenses (IOLs).
Laboratory setting, Miyata Eye Clinic, Hiroshima, Japan.
The equilibrium water content (amount of water absorbed per weight of the resin x 100) in 2 hydrophobic acrylic IOLs (AcrySof MA60BM [Alcon] and Sensar AR40 [AMO]) was calculated at 30 degrees C, 40 degrees C, and 50 degrees C. The 2 IOLs were also subjected to 3 changes in temperature: from 37 degrees C to 35 degrees C, 39 degrees C to 35 degrees C, and 41 degrees C to 35 degrees C. They were incubated in physiological saline at the higher temperature for 2 hours and at the lower temperature for 30 days before being examined for glistening formation.
The water content was higher in the AR40 IOL than in the MA60BM IOL at all temperatures. A temperature-dependent increase in water content was seen in both IOLs, greater in the MA60BM. With a temperature change from 37 degrees C to 35 degrees C, glistening formation was not observed in either IOL. With a temperature change from 39 degrees C to 35 degrees C, glistenings were observed in the MA60BM IOL, and with a temperature change from 41 degrees C to 35 degrees C, they were observed in both IOLs.
The change in the equilibrium water content caused by temperature changes between 30 degrees C and 40 degrees C is an important factor in glistening formation, and thus an IOL featuring less temperature-dependent water absorption is less likely to form glistenings.
研究丙烯酸人工晶状体（IOL）中温度与吸水性之间的可能关系。
日本广岛宫田眼科诊所的实验室环境。
计算2种疏水丙烯酸IOL（AcrySof MA60BM [爱尔康]和Sensar AR40 [AMO]）在30℃、40℃和50℃时的平衡水含量（每克树脂吸收的水量×100）。这2种IOL还经历了3次温度变化：从37℃降至35℃、从39℃降至35℃以及从41℃降至35℃。它们在较高温度下于生理盐水中孵育2小时，在较低温度下孵育30天，然后检查是否有闪烁形成。
在所有温度下，AR40 IOL的含水量均高于MA60BM IOL。两种IOL均出现了随温度升高的含水量增加，MA60BM增加得更多。温度从37℃降至35℃时，两种IOL均未观察到闪烁形成。温度从39℃降至35℃时，MA60BM IOL中观察到了闪烁，温度从41℃降至35℃时，两种IOL中均观察到了闪烁。
30℃至40℃之间温度变化引起的平衡水含量变化是闪烁形成的一个重要因素，因此，水吸收对温度依赖性较小的IOL形成闪烁的可能性较小。
