新的疏水性丙烯酸人工晶状体中的闪光形成。
Glistening formation in a new hydrophobic acrylic intraocular lens.
机构信息
The David J. Apple International Laboratory for Ocular Pathology, Department of Ophthalmology, University of Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany.
Department of Ophthalmology, The Third Affiliated Hospital of Wenzhou Medical University, 108# Wansong Road, Rui'an, Zhejiang, 325200, China.
出版信息
BMC Ophthalmol. 2020 May 6;20(1):186. doi: 10.1186/s12886-020-01430-z.
BACKGROUND
The formation of fluid-filled microvacuoles, termed glistenings, is a common complication of intraocular lenses (IOLs) made from hydrophobic acrylate. Using our well-established in-vitro laboratory method, we evaluated a new IOL material's resistance to glistening formation.
METHODS
An in-vitro stress test for glistening induction was performed on 20 samples of hydrophobic acrylic IOLs: ten of the new Eyecryl ASHFY600 (Biotech Vision Care, Ahmedabad, India) compared with ten samples of AcrySof IQ SN60WF (Alcon, Fort Worth, USA). The number of microvacuoles per square millimetre (MV/mm) was evaluated in five sections of each IOL. The results for each model were compared and rated on a modified Miyata Scale for grading glistening severity.
RESULTS
In all cases, glistening number was higher in the central section of the IOL optic than in the periphery. Mean number of MV/mm was highest in the central part of the AcrySof IQ SN60WF, with 41.84 (±27.67) MVs/mm. The lowest number of glistenings was found in the five sections of the Eyecryl ASHFY600 with 0.52 (±0.24) MVs/mm. Mean value of the Eyecryl ASHFY600 IOL, using the Miyata Scale, was Zero.
CONCLUSION
In this in-vitro laboratory study, the new hydrophobic acrylic IOL showed a high resistance to microvacuole formation. Results from this in-vitro study suggest that glistening numbers will be low in clinical use in the Eyecryl ASHFY600.
背景
充满液体的微泡的形成，称为闪光，是由疏水性丙烯酸酯制成的眼内透镜（IOL）的常见并发症。我们使用成熟的体外实验室方法，评估了一种新型 IOL 材料对闪光形成的抵抗力。
方法
对 20 个疏水丙烯酸 IOL 样本进行了闪光诱导的体外应激测试：十个新型 Eyecryl ASHFY600（印度艾哈迈达巴德 Biotech Vision Care）与十个 AcrySof IQ SN60WF（美国福斯特城 Alcon）样本进行比较。在每个 IOL 的五个部分评估每平方毫米的微泡数（MV/mm）。对每个模型的结果进行比较，并根据 Miyata 分级标准对闪光严重程度进行分级。
结果
在所有情况下，IOL 光学中央部分的闪光数量均高于周边部分。AcrySof IQ SN60WF 的中央部分的平均 MV/mm 最高，为 41.84（±27.67）MV/mm。Eyecryl ASHFY600 的五个部分的闪光数量最低，为 0.52（±0.24）MV/mm。使用 Miyata 分级标准，Eyecryl ASHFY600 IOL 的平均值为零。
结论
在这项体外实验室研究中，新型疏水性丙烯酸 IOL 显示出对微泡形成的高抵抗力。这项体外研究的结果表明，Eyecryl ASHFY600 在临床使用中闪光数量将较低。
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