Ludivico C L, Myers A R
Arthritis Rheum. 1979 Jan;22(1):19-24. doi: 10.1002/art.1780220104.
Seventeen patients with characteristic disseminated gonococcal arthritis-dermatitis syndrome were studied for the presence of immune complexes, and circulating gonococcal antigen and antibody. The two immune complex techniques, monoclonal rheumatoid factor assay and cryoglobulin survey, did not reveal any consistent abnormalities. Complement levels (CH50, C'3, C'4) were not consistent with peripheral consumption except in 2 patients with coinciding systemic lupus erythematosus. Gonococcal antibody was detected in 47% of patients when they presented with the syndrome. However, gonococcal antigen was not found in either serum or synovial fluid. These results do not support the hypothesis that circulating immune complexes are involved in the pathogenesis of disseminated gonococcal arthritis-dermatitis syndrome.
对17例具有典型播散性淋菌性关节炎-皮炎综合征的患者进行了免疫复合物、循环淋菌抗原及抗体检测。两种免疫复合物检测技术，即单克隆类风湿因子检测及冷球蛋白检测，均未发现任何一致的异常情况。补体水平（CH50、C'3、C'4）除2例合并系统性红斑狼疮的患者外，与外周消耗情况不符。47%的患者在出现该综合征时检测到淋菌抗体。然而，在血清及滑液中均未发现淋菌抗原。这些结果不支持循环免疫复合物参与播散性淋菌性关节炎-皮炎综合征发病机制的假说。
