Manicourt D H, Orloff S
Arthritis Rheum. 1982 May;25(5):574-8. doi: 10.1002/art.1780250513.
Immune complexes from serum and synovial fluid were detected by the C1q binding assay in 12 patients with disseminated gonococcal infection. Since immune complexes were regularly higher in synovial fluids than in paired sera and were not detected by the monoclonal rheumatoid factor radioimmunoassay, we suggest that IgM may be present in these complexes and that this represents a primary immune response. In contrast, only 2 of 10 patients with local gonococcal infection were slightly positive both with the C1q assay and the monoclonal rheumatoid factor assay. In patients with disseminated gonococcal infection, immune complexes closely paralleled the disease activity and negatively correlated with complement levels. Synovial fluid immune complexes seem to occur in the early and aseptic phase of polyarthritis and to aid the entrance of circulating gonococcal organisms. From the results of our study, it seems that immunologic processes initiate and/or sustain inflammation in disseminated gonococcal infections that appear, at least in part, as a form of reactive arthritis.
通过C1q结合试验检测了12例播散性淋球菌感染患者血清和滑液中的免疫复合物。由于滑液中的免疫复合物通常高于配对血清中的免疫复合物，且单克隆类风湿因子放射免疫测定未检测到，我们认为这些复合物中可能存在IgM，这代表了一种原发性免疫反应。相比之下，10例局部淋球菌感染患者中只有2例C1q试验和单克隆类风湿因子试验均呈弱阳性。在播散性淋球菌感染患者中，免疫复合物与疾病活动密切相关，与补体水平呈负相关。滑液免疫复合物似乎出现在多关节炎的早期无菌阶段，并有助于循环中的淋球菌进入。从我们的研究结果来看，免疫过程似乎在播散性淋球菌感染中引发和/或维持炎症，这种感染至少部分表现为反应性关节炎的一种形式。
