Walker L C, Ahlin T D, Tung K S, Williams R C
Ann Intern Med. 1978 Jul;89(1):28-33. doi: 10.7326/0003-4819-89-1-28.
Circulating immune complexes were detected by the Raji-cell radioassay or the C1q solid-phase assay in 13 of 17 patients with disseminated gonococcal infection. In contrast, only three of 20 patients with local gonococcal infection and four of 40 normal persons were positive. The immune complexes were found to be 19S or larger in size, and complement abnormalities suggestive of complement activation showed some correlation with the levels of immune complexes in disseminated gonorrheal infection. These results indicate that in addition to bacterial dissemination, circulating immune complexes may be involved in the pathogenesis of disseminated gonococcal syndrome.
采用拉吉细胞放射测定法或C1q固相测定法，在17例播散性淋球菌感染患者中的13例检测到循环免疫复合物。相比之下，20例局部淋球菌感染患者中只有3例呈阳性，40例正常人中只有4例呈阳性。发现免疫复合物大小为19S或更大，提示补体激活的补体异常与播散性淋病感染中的免疫复合物水平存在一定相关性。这些结果表明，除了细菌播散外，循环免疫复合物可能参与了播散性淋球菌综合征的发病机制。
