来自双交叉黏合的伪六边形二维DNA晶体。

Pseudohexagonal 2D DNA crystals from double crossover cohesion.

作者信息

Ding Baoquan, Sha Ruojie, Seeman Nadrian C

机构信息

Department of Chemistry, New York University, New York, NY 10003, USA.

出版信息

J Am Chem Soc. 2004 Aug 25;126(33):10230-1. doi: 10.1021/ja047486u.

DOI:10.1021/ja047486u

PMID:15315420

Abstract

Two-dimensional pseudohexagonal trigonal arrays have been constructed by self-assembly from DNA. The motif used is a bulged-junction DNA triangle whose edges and extensions are DNA double crossover (DX) molecules, rather than conventional DNA double helices. Experiments were performed to establish whether the success of this system results from the added stiffness of DX molecules or the presence of two sticky ends at the terminus of each edge. Removal of one sticky end precludes lattice formation, suggesting that it is the double sticky end that is the primary factor enabling lattice formation.

摘要

通过DNA自组装构建了二维伪六边形三角阵列。所使用的基序是一个凸起连接的DNA三角形，其边和延伸部分是DNA双交叉（DX）分子，而不是传统的DNA双螺旋。进行了实验以确定该系统的成功是源于DX分子增加的刚性还是每条边末端存在的两个粘性末端。去除一个粘性末端会阻止晶格形成，这表明正是双粘性末端是促成晶格形成的主要因素。