Harma Mehmet, Harma Muge, Kocyigit Abdurrahim
Department of Obstetrics and Gynecology, University of Harran Medical School, Sanliurfa, Turkey.
Acta Obstet Gynecol Scand. 2004 Sep;83(9):857-60. doi: 10.1111/j.0001-6349.2004.00608.x.
Normal pregnant women are known to have increased oxidative stress and lipid peroxidation (which can be estimated by protein carbonyl concentration) but offsetting antioxidant protection (of which plasma thiols are an important component).
This study set out to compare levels of these markers in normal pregnant women and patients with complete hydatidiform mole (CHM).
Blood was taken from 41 healthy pregnant women and 39 patients with CHM attending a university hospital, and protein carbonyl and thiol levels determined spectrophotometrically on plasma. Statistical analysis of the results was performed using Student's t-test and Pearson's correlation.
Patients with CHM were found to have significantly higher levels of protein carbonyls and lower (but non-significant) levels of thiols.
The results may indicate oxidative stress as a feature of CHM.
众所周知，正常孕妇的氧化应激和脂质过氧化作用增强（可通过蛋白质羰基浓度进行评估），但同时存在抵消性的抗氧化保护作用（血浆硫醇是其中的重要组成部分）。
本研究旨在比较正常孕妇和完全性葡萄胎（CHM）患者中这些标志物的水平。
从一家大学医院的41名健康孕妇和39名CHM患者采集血液，采用分光光度法测定血浆中的蛋白质羰基和硫醇水平。使用学生t检验和皮尔逊相关性对结果进行统计分析。
发现CHM患者的蛋白质羰基水平显著更高，硫醇水平更低（但无统计学意义）。
结果可能表明氧化应激是CHM的一个特征。
