Chuang M-L, Lin I-F, Vintch J R E
Division of Pulmonary and Critical Care Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan.
Intern Med J. 2004 Aug;34(8):469-74. doi: 10.1111/j.1445-5994.2004.00651.x.
Maximal oxygen uptake (VO(2max)) and exercise modalities such as walking and standard pulmonary function testing are measurements that have been used by the surgical community as an indication of a patient's current exercise capacity to predict operative outcomes. There are equations available in published reports that allow an estimate of VO(2max) to be made by measuring a combination of the distance walked as well as lung function in patients with chronic obstructive -pulmonary disease (COPD).
The aim of the present study was to determine if estimates of VO(2max) and measured VO(2max) based on predictive equations are useful in individuals with COPD.
Twenty-eight male patients (mean age 68 years) with a mean forced expiratory volume in 1 s of 1.3 L were enrolled in the study after determining that they could perform a maximal exercise study. The estimated VO(2max) using equations reported by Chuang et al. and Cahalin et al. was cross-validated with the measured VO(2max) determined during cardiopulmonary exercise testing.
The mean estimated VO(2max) using the pre-diction equation did not differ from the mean measured VO(2max) (1.13 vs 1.18 L/min, respectively; P = 0.25). However, the scattered relationship between the measured and the estimated VO(2max) did not support the use of this equation to predict an individual's performance. The prediction equations currently available in published reports significantly underestimate the measured VO(2max) (P < 0.05-10(-12)).
It is recommended that VO(2max) is measured rather than estimated using the prediction equations when a VO(2max) measurement is used for clinical decision-making.
最大摄氧量（VO₂max）以及诸如步行等运动方式和标准肺功能测试，一直被外科界用作衡量患者当前运动能力以预测手术结果的指标。已发表的报告中有一些公式，可通过测量慢性阻塞性肺疾病（COPD）患者的步行距离和肺功能组合来估算VO₂max。
本研究的目的是确定基于预测方程估算的VO₂max和实测VO₂max对COPD患者是否有用。
在确定28名男性患者（平均年龄68岁）能够进行最大运动研究后，将其纳入研究，这些患者1秒用力呼气量平均为1.3L。使用Chuang等人和Cahalin等人报告的公式估算的VO₂max与心肺运动测试期间测定的实测VO₂max进行交叉验证。
使用预测方程估算的平均VO₂max与实测平均VO₂max无差异（分别为1.13 vs 1.18L/min；P = 0.25）。然而，实测VO₂max与估算VO₂max之间的离散关系不支持使用该方程预测个体表现。已发表报告中目前可用的预测方程显著低估了实测VO₂max（P < 0.05 - 10⁻¹²）。
当VO₂max测量用于临床决策时，建议测量VO₂max而非使用预测方程进行估算。
