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本文引用的文献

1
Structural comparison of the integrative and conjugative elements R391, pMERPH, R997, and SXT.整合性接合元件R391、pMERPH、R997和SXT的结构比较
Plasmid. 2004 Jan;51(1):12-23. doi: 10.1016/j.plasmid.2003.10.003.
2
SOS response promotes horizontal dissemination of antibiotic resistance genes.SOS 应答促进抗生素抗性基因的水平传播。
Nature. 2004 Jan 1;427(6969):72-4. doi: 10.1038/nature02241. Epub 2003 Dec 21.
3
Evidence for the translation initiation of leaderless mRNAs by the intact 70 S ribosome without its dissociation into subunits in eubacteria.在真细菌中，无领导序列的信使核糖核酸（mRNA）通过完整的70S核糖体起始翻译，而核糖体无需解离成亚基的证据。
J Biol Chem. 2004 Mar 5;279(10):8539-46. doi: 10.1074/jbc.M308784200. Epub 2003 Dec 11.
4
The CTXphi repressor RstR binds DNA cooperatively to form tetrameric repressor-operator complexes.CTXphi 阻遏蛋白 RstR 协同结合 DNA，形成四聚体阻遏蛋白-操纵基因复合物。
J Biol Chem. 2004 Jan 23;279(4):2640-7. doi: 10.1074/jbc.M311109200. Epub 2003 Nov 10.
5
Control of SXT integration and excision.SXT整合与切除的控制
J Bacteriol. 2003 Sep;185(17):5045-54. doi: 10.1128/JB.185.17.5045-5054.2003.
6
PromH: Promoters identification using orthologous genomic sequences.PromH：利用直系同源基因组序列进行启动子识别。
Nucleic Acids Res. 2003 Jul 1;31(13):3540-5. doi: 10.1093/nar/gkg525.
7
Class I integrons and SXT elements in El Tor strains isolated before and after 1992 Vibrio cholerae O139 outbreak, Calcutta, India.1992年印度加尔各答霍乱弧菌O139暴发前后分离的埃尔托菌株中的I类整合子和SXT元件
Emerg Infect Dis. 2003 Apr;9(4):500-2. doi: 10.3201/eid0904.020317.
8
Comparison of SXT and R391, two conjugative integrating elements: definition of a genetic backbone for the mobilization of resistance determinants.SXT和R391这两种接合整合元件的比较：抗性决定因子转移遗传骨架的定义
Cell Mol Life Sci. 2002 Dec;59(12):2065-70. doi: 10.1007/s000180200006.
9
Genomic and functional analyses of SXT, an integrating antibiotic resistance gene transfer element derived from Vibrio cholerae.SXT的基因组和功能分析，SXT是一种源自霍乱弧菌的整合型抗生素抗性基因转移元件。
J Bacteriol. 2002 Aug;184(15):4259-69. doi: 10.1128/JB.184.15.4259-4269.2002.
10
Vibrio cholerae O1 outbreak isolates in Mozambique and South Africa in 1998 are multiple-drug resistant, contain the SXT element and the aadA2 gene located on class 1 integrons.1998年莫桑比克和南非霍乱弧菌O1群暴发分离株具有多重耐药性，含有SXT元件和位于1类整合子上的aadA2基因。
J Antimicrob Chemother. 2001 Dec;48(6):827-38. doi: 10.1093/jac/48.6.827.

鉴定控制SXT接合转移的操纵子和启动子。

Identification of operators and promoters that control SXT conjugative transfer.

作者信息

Beaber John W, Waldor Matthew K

机构信息

Department of Microbiology, Tufts University School of Medicine, 136 Harrison Ave., Jaharis 425, Boston, MA 02111, USA.

出版信息

J Bacteriol. 2004 Sep;186(17):5945-9. doi: 10.1128/JB.186.17.5945-5949.2004.

DOI:10.1128/JB.186.17.5945-5949.2004
PMID:15317801
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC516836/
Abstract

Transfer of SXT, a Vibrio cholerae-derived integrating conjugative element that encodes multiple antibiotic resistance genes, is repressed by SetR, a lambda434 cI-related repressor. Here we identify divergent promoters between s086 and setR that drive expression of the regulators of SXT transfer. One transcript encodes the activators of transfer, setC and setD. The second transcript codes for SetR and, like the cI transcript of lambda, is leaderless. SetR binds to four operators located between setR and s086; the locations and relative affinities of these sites suggest a model for regulation of SXT transfer.

摘要

SXT是一种源自霍乱弧菌的整合性接合元件，编码多种抗生素抗性基因，其转移受SetR（一种与λ434 cI相关的阻遏物）抑制。在此，我们鉴定出s086和setR之间的不同启动子，它们驱动SXT转移调节因子的表达。一种转录本编码转移激活因子setC和setD。第二种转录本编码SetR，并且与λ的cI转录本一样，没有前导序列。SetR与位于setR和s086之间的四个操纵子结合；这些位点的位置和相对亲和力提示了一种SXT转移调控模型。