Georgiou D, Brundage B H
Division of Cardiology, Harbor-UCLA Medical Center, Torrance, California 90509.
Clin Cardiol. 1992 Jan;15(1):5-16. doi: 10.1002/clc.4960150104.
The importance of treatment in systemic hypertension and cardiovascular morbidity and mortality has been established. Although systemic hypertension is the most important factor in the pathogenesis of left ventricular hypertrophy, other factors such as catecholamines and renin-angiotensin system may be involved. Increased left ventricular mass causes reduction in coronary reserve and may lead to acute ischemic events. Equally efficacious antihypertensive agents may have diverse effects on left ventricular hypertrophy and left ventricular function. New tomographic techniques with improved spatial resolution are emerging in the evaluation of left ventricular mass and may therefore provide better assessment of changes in left ventricular mass. With improved measures of left ventricular mass the question as to whether regression of left ventricular mass provides an additional benefit beyond control of blood pressure in hypertensive individuals may be finally answered.
治疗在系统性高血压以及心血管发病率和死亡率中的重要性已得到确立。尽管系统性高血压是左心室肥厚发病机制中最重要的因素，但其他因素如儿茶酚胺和肾素 - 血管紧张素系统也可能参与其中。左心室质量增加会导致冠状动脉储备减少，并可能引发急性缺血事件。同样有效的抗高血压药物对左心室肥厚和左心室功能可能有不同的影响。在评估左心室质量方面，具有更高空间分辨率的新断层扫描技术正在兴起，因此可能会更好地评估左心室质量的变化。随着左心室质量测量方法的改进，关于左心室质量的逆转在高血压个体中除了控制血压之外是否还能带来额外益处这一问题最终可能会得到解答。
