Balogun M O, Dunn F G
Department of Medical Cardiology, Stobhill General Hospital, Glasgow, UK.
J Hum Hypertens. 1990 Oct;4 Suppl 4:29-32; discussion 32-4.
Left ventricular hypertrophy is an ominous prognostic factor for all the cardiovascular complications of hypertension. Treatment has undoubtedly improved the outlook, particularly in patients with congestive cardiac failure. It has recently been shown that the hypertrophy process itself can be regressed by control of hypertension. The principal factor of importance in this regression process is the fall in blood pressure. Although experimental studies suggest that the renin-angiotensin-aldosterone (RAA) system and the sympathetic nervous system (SNS) both play a role in regression, clinical studies in this regard are suggestive but not conclusive. Left ventricular function appears well preserved with the control of blood pressure and parallel reduction in pressure and left ventricular mass is likely to have no adverse effect on myocardial perfusion. The implications of regression of hypertrophy and the patient's long term prognosis have not yet been determined.
左心室肥厚是高血压所有心血管并发症的一个不祥预后因素。治疗无疑改善了预后，尤其是在充血性心力衰竭患者中。最近已表明，通过控制高血压，肥厚过程本身可以逆转。在这个逆转过程中重要的主要因素是血压下降。尽管实验研究表明肾素 - 血管紧张素 - 醛固酮（RAA）系统和交感神经系统（SNS）在逆转中都起作用，但这方面的临床研究只是提示性的而非结论性的。随着血压得到控制，左心室功能似乎得到很好的保留，压力和左心室质量的平行降低可能对心肌灌注没有不利影响。肥厚逆转的意义和患者的长期预后尚未确定。
