Jourjon Marie-Françoise, Jasson Sylvain, Marcel Jacques, Ngom Baba, Mangin Brigitte
INRA, Unité de Biométrie et d'Intelligence Artificielle B.P. 27, 31326 Castanet-Tolosan, France.
Bioinformatics. 2005 Jan 1;21(1):128-30. doi: 10.1093/bioinformatics/bth481. Epub 2004 Aug 19.
The aim of the MCQTL software package is to perform QTL mapping in multi-cross designs. It allows the analysis of the usual populations derived from inbred lines and can link the families by assuming that the QTL locations are the same in all of them. Moreover, a diallel modelling of the QTL genotypic effects is allowed in multiple related families. The implemented model is a linear regression model. A composite interval mapping and an iterative QTL mapping are implemented to deal with multiple QTL models. Marker cofactor selections by forward or backward stepwise methods are implemented as well as computation of threshold test value by permutation.
The program is available on request after signing a licence agreement; free of charge for academic and non-profit organizations at http://www.genoplante.org (Bioinformatics products).
MCQTL软件包的目的是在多杂交设计中进行QTL定位。它允许对源自近交系的常见群体进行分析，并且通过假设所有群体中的QTL位置相同来关联各个家系。此外，在多个相关家系中允许对QTL基因型效应进行双列杂交建模。所实现的模型是线性回归模型。实现了复合区间作图和迭代QTL作图以处理多QTL模型。还实现了通过向前或向后逐步方法进行标记辅助因子选择以及通过置换计算阈值检验值。
签署许可协议后可应要求提供该程序；对于学术和非营利组织，可在http://www.genoplante.org（生物信息学产品）免费获取。
