Levitz M, Raju U, Boccardo F, Arcuri F, Castagnetta L
Department of Obstetrics and Gynecology, New York University Medical Center, NY.
Cancer Detect Prev. 1992;16(1):57-9.
Gross cystic disease (GCD) of the breast imparts a minimal risk for the development of breast cancer. Relative to serum, breast cyst fluid (BCF) in patients with GCD is highly concentrated in androgens, estrogens, certain enzymes, and bioactive polypeptides. In addition, the cations, sodium and potassium, vary markedly and inversely in BCF. We have focused on the levels of estriol-3-sulfate (E3S), which are several orders of magnitude greater in BCF than in blood. In this preliminary study, about 55 specimens of BCF were analyzed for E3S, its possible precursors, estrone sulfate (E1S) and dehydroisoandrosterone sulfate (DHAS), and the cations, sodium and potassium. The data were analyzed statistically by linear regression analysis. E3S correlated directly with both E1S and DHAS (p less than 0.002), and inversely with the Na/K ratio (p less than 0.003). Low Na/K ratio has been associated with secretory processes in cyst epithelium. The data suggest that E3S may originate via 16 alpha-hydroxylation of estrogen in the cyst and that elevated E3S levels may be indicative of a secretory epithelium. This is part of an ongoing prospective study involving 400 subjects with GCD to see whether hormonal and enzymic profiles can be related to cancer risk.
乳腺大囊性病（GCD）发展为乳腺癌的风险极小。相对于血清，GCD患者的乳腺囊液（BCF）中雄激素、雌激素、某些酶和生物活性多肽高度浓缩。此外，BCF中的阳离子钠和钾变化显著且呈负相关。我们重点关注了硫酸雌三醇（E3S）的水平，其在BCF中的含量比血液中高几个数量级。在这项初步研究中，对约55份BCF样本进行了E3S、其可能的前体硫酸雌酮（E1S）和硫酸脱氢表雄酮（DHAS）以及阳离子钠和钾的分析。通过线性回归分析对数据进行统计学分析。E3S与E1S和DHAS均呈正相关（p小于0.002），与钠钾比呈负相关（p小于0.003）。低钠钾比与囊肿上皮的分泌过程有关。数据表明，E3S可能通过囊肿中雌激素的16α-羟基化产生，E3S水平升高可能表明存在分泌性上皮。这是一项正在进行的前瞻性研究的一部分，该研究涉及400名GCD患者，以观察激素和酶谱是否与癌症风险相关。
