Raju U, Levitz M, Jacobowitz G, Fleisher M, Bencsath F A, Field F H, Breed C N, Naganuma H, Bradlow H L
Department of Obstetrics and Gynecology, New York University Medical School, New York 10016.
Steroids. 1987 Oct-Dec;50(4-6):559-74. doi: 10.1016/0039-128x(87)90039-0.
The concentration of 16 alpha-hydroxydehydroepiandrosterone-3-sulfate (16 alpha-OHDHAS) was determined in 29 samples of human breast cyst fluid (BCF) and in 15 of these, androst-5-ene-3 beta,16 alpha,17 beta-triol-3-sulfate (A-TriolS) was also assayed. The median value of both was about 100 ng/mL and the ranges were from 1.4 to about 1800 ng/mL. There was a significant association in the values for the two sulfates (p less than 0.05). These concentrations are consistent with a role for 16 alpha-hydroxy androgens as possible precursors for estriol-3-sulfate. The latter is highly elevated relative to other body fluids in BCF. The androgens also correlated directly with the concentrations of K+, an indicator of apocrine proliferation of breast cysts.
测定了29份人乳腺囊肿液（BCF）样本中16α-羟基脱氢表雄酮-3-硫酸盐（16α-OHDHAS）的浓度，并对其中15份样本同时检测了雄甾-5-烯-3β,16α,17β-三醇-3-硫酸盐（A-TriolS）。两者的中位数约为100 ng/mL，范围为1.4至约1800 ng/mL。两种硫酸盐的值之间存在显著相关性（p<0.05）。这些浓度与16α-羟基雄激素作为硫酸雌三醇可能前体的作用一致。相对于BCF中的其他体液，硫酸雌三醇高度升高。雄激素也与乳腺囊肿顶泌汗腺增殖指标K+的浓度直接相关。
