Lee Kwang-Jae, Kindt S, Tack Jan
Department of Internal Medicine, Division of Gastroenterology, University Hospital Gasthuisberg, University of Leuven, Herestraat 49, B-3000 Leuven, Belgium.
Best Pract Res Clin Gastroenterol. 2004 Aug;18(4):707-16. doi: 10.1016/j.bpg.2004.04.007.
Functional dyspepsia is a highly prevalent symptom complex and a heterogeneous disorder. Recent studies showed potential associations between specific pathophysiologic disturbances and dyspeptic symptoms. Delayed gastric emptying reported in about 30% of patients with functional dyspepsia is associated with the symptoms of postprandial fullness, nausea, and vomiting. Impaired gastric accommodation present in 40% of functional dyspepsia patients is found to be associated with early satiety. Hypersensitivity to gastric distension is observed in 37% of functional dyspepsia patients and associated with the symptoms of postprandial pain, belching, and weight loss. Psychosocial factors and altered response to duodenal lipids or acid have also been identified as pathophysiologic mechanisms.
功能性消化不良是一种非常普遍的症状复合体，也是一种异质性疾病。最近的研究表明特定病理生理紊乱与消化不良症状之间存在潜在关联。约30%的功能性消化不良患者存在胃排空延迟，这与餐后饱胀、恶心和呕吐症状相关。40%的功能性消化不良患者存在胃容受性受损，这被发现与早饱相关。37%的功能性消化不良患者存在胃扩张超敏反应，这与餐后疼痛、嗳气和体重减轻症状相关。心理社会因素以及对十二指肠脂质或酸的反应改变也已被确定为病理生理机制。
