Tack Jan, Lee K J
Department of Internal Medicine, Division of Gastroenterology, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium.
J Clin Gastroenterol. 2005 May-Jun;39(5 Suppl 3):S211-6. doi: 10.1097/01.mcg.0000156109.97999.d1.
Functional dyspepsia is a highly prevalent symptom complex and a heterogenous disorder. Recent studies showed potential associations between specific pathophysiologic disturbances and dyspeptic symptoms. Delayed gastric emptying reported in about 30% of patients with functional dyspepsia is associated with the symptoms of postprandial fullness, nausea, and vomiting. Impaired gastric accommodation present in 40% of functional dyspepsia patients is found to be associated with early satiety. Hypersensitivity to gastric distension is observed in 37% of functional dyspepsia patients and associated with the symptoms of postprandial pain, belching, and weight loss. Psychosocial factors and altered response to duodenal lipids or acid have also been identified as pathophysiologic mechanisms. Therapeutic options are still limited but targeted therapy directed at the underlying pathophysiology seems desirable. Thus, efforts to further elucidate underlying pathophysiologic mechanisms and identify the appropriate patient population using some type of pathophysiologic testing will be required.
功能性消化不良是一种高度常见的症状复合体，也是一种异质性疾病。最近的研究表明，特定的病理生理紊乱与消化不良症状之间存在潜在关联。约30%的功能性消化不良患者存在胃排空延迟，这与餐后饱胀、恶心和呕吐症状相关。40%的功能性消化不良患者存在胃容受性受损，这被发现与早饱相关。37%的功能性消化不良患者存在胃扩张高敏反应，这与餐后疼痛、嗳气和体重减轻症状相关。心理社会因素以及对十二指肠脂质或酸的反应改变也已被确定为病理生理机制。治疗选择仍然有限，但针对潜在病理生理学的靶向治疗似乎是可取的。因此，需要努力进一步阐明潜在的病理生理机制，并使用某种病理生理测试来确定合适的患者群体。
