Ruf Wolfram
Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
Trends Immunol. 2004 Sep;25(9):461-4. doi: 10.1016/j.it.2004.07.002.
Activation of coagulation by tissue factor (TF) is frequently observed in sepsis syndrome and is documented in certain viral hemorrhagic fevers. Coagulation protease complexes signal by activating the G-protein coupled, protease-activated receptors that regulate inflammation. Blockade of TF attenuates lethality in experimental models of Ebola virus infection but - similar to findings in bacterial sepsis - reduction of inflammation, rather than attenuation of coagulation, predicts survival of treated animals. Thus, targeting TF appears to aid the antiviral immune response in hemorrhagic fevers, and further studies are encouraged to define how TF-dependent signaling regulates immunity.
组织因子（TF）激活凝血在脓毒症综合征中经常可见，并且在某些病毒性出血热中也有记录。凝血蛋白酶复合物通过激活调节炎症的G蛋白偶联蛋白酶激活受体来发出信号。在埃博拉病毒感染的实验模型中，阻断TF可降低致死率，但与细菌脓毒症的研究结果相似，炎症的减轻而非凝血的减弱预示着治疗动物的存活。因此，靶向TF似乎有助于出血热中的抗病毒免疫反应，鼓励进一步研究来确定TF依赖性信号传导如何调节免疫。
