螺喹唑啉酮类化合物作为新型、高效且选择性的磷酸二酯酶7（PDE7）抑制剂。第2部分：5,8-二取代衍生物的优化
Spiroquinazolinones as novel, potent, and selective PDE7 inhibitors. Part 2: Optimization of 5,8-disubstituted derivatives.
作者信息
Bernardelli Patrick, Lorthiois Edwige, Vergne Fabrice, Oliveira Chrystelle, Mafroud Abdel-Kader, Proust Emmanuelle, Pham Nga, Ducrot Pierre, Moreau François, Idrissi Moulay, Tertre Anita, Bertin Bernadette, Coupe Magali, Chevalier Eric, Descours Arnaud, Berlioz-Seux Françoise, Berna Patrick, Li Mei
机构信息
Pfizer Global Research and Development, 3-9 rue de la Loge 94265 Fresnes, France.
出版信息
Bioorg Med Chem Lett. 2004 Sep 20;14(18):4627-31. doi: 10.1016/j.bmcl.2004.07.010.
PMID:15324877
Abstract
The optimization of 5,8-disubstituted spirocyclohexane-quinazolinones into potent, selective, soluble PDE7 inhibitors with acceptable in vivo pharmacokinetic parameters is presented.
摘要
本文介绍了将5,8-二取代螺环己烷喹唑啉酮优化为具有良好体内药代动力学参数的强效、选择性、可溶性磷酸二酯酶7（PDE7）抑制剂的过程。
Zotero 插件