同时感染艾滋病毒的丙型肝炎病毒患者的治疗。

Treatment of the hepatitis C virus in patients coinfected with HIV.

作者信息

Khalili Mandana, Proietti Nicole

机构信息

University of California, San Francisco, San Francisco General Hospital, 1001 Potrero Avenue, NH-3D, San Francisco, CA 94110, USA.

出版信息

Gastroenterol Clin North Am. 2004 Sep;33(3):479-96, vii-viii. doi: 10.1016/j.gtc.2004.04.002.

DOI:10.1016/j.gtc.2004.04.002

PMID:15324939

Abstract

Hepatitis C virus (HCV) coinfection is common among individuals with HIV, and the progression of liver disease is accelerated in coinfected individuals compared with those with HCV alone. HCV coinfection also can decrease tolerability of highly active antiretroviral therapy. Additionally, the presence of HCV appears to increase morbidity and mortality in these individuals, and as such the management of both HCV and HIV in coinfected individuals requires careful consideration. Although coinfected patients should be considered for HCV therapy, the limited information to date indicates a lower rate of virologic response with current HCV therapies. Moreover, interactions between HCV and HIV antiviral medications may occur and potentially affect treatment efficacy. Thus, the decision to undertake HCV treatment must be individualized.

摘要

丙型肝炎病毒（HCV）合并感染在艾滋病毒感染者中很常见，与单纯感染HCV的个体相比，合并感染个体的肝病进展加速。HCV合并感染还会降低高效抗逆转录病毒治疗的耐受性。此外，HCV的存在似乎会增加这些个体的发病率和死亡率，因此，对合并感染个体的HCV和HIV管理都需要仔细考虑。尽管应考虑对合并感染患者进行HCV治疗，但迄今为止有限的信息表明，目前的HCV治疗的病毒学应答率较低。此外，HCV和HIV抗病毒药物之间可能会发生相互作用，并可能影响治疗效果。因此，进行HCV治疗的决定必须个体化。