新出现的真菌疾病：宿主的重要性。

Emerging fungal diseases: the importance of the host.

作者信息

Procop Gary W, Roberts Glenn D

机构信息

Section of Clinical Microbiology, The Cleveland Clinic Foundation, L40, 9500 Euclid Avenue, Cleveland, OH 44195, USA.

出版信息

Clin Lab Med. 2004 Sep;24(3):691-719, vi-vii. doi: 10.1016/j.cll.2004.05.004.

DOI:10.1016/j.cll.2004.05.004

PMID:15325061

Abstract

More yeasts and molds are now recognized to cause more human disease than ever before. This development is not due to a change in the virulence of these fungi, but rather to changes in the human host. These changes include immunosuppression secondary to the pandemic of HIV, the use of life-saving advances in chemotherapy and organ transplantation, and the use of corticosteroids and other immunosuppressive agents to treat a variety of diseases. Fungi that were once considered common saprophytes are now recognized as potential pathogens in these patients. This situation necessitates better communication than ever between the clinician, pathologist, and clinical mycologist to ensure the prompt and accurate determination of the cause of fungal diseases.

摘要

如今，人们认识到酵母和霉菌引发的人类疾病比以往任何时候都多。这种情况的出现并非是因为这些真菌的毒力发生了变化，而是由于人类宿主发生了改变。这些变化包括继发于艾滋病大流行的免疫抑制、化疗和器官移植领域挽救生命的进展的应用，以及使用皮质类固醇和其他免疫抑制剂来治疗各种疾病。曾经被认为是常见腐生菌的真菌，现在被认为是这些患者的潜在病原体。这种情况使得临床医生、病理学家和临床真菌学家之间需要比以往任何时候都更好地沟通，以确保迅速准确地确定真菌疾病的病因。