Zhu W, Chiu L C M, Ooi V E C, Chan P K S, Ang P O
Department of Biology, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China.
Int J Antimicrob Agents. 2004 Sep;24(3):279-83. doi: 10.1016/j.ijantimicag.2004.02.022.
A sulphated polysaccharide (SP2) was isolated from the brown alga Sargassum patens. SP2 inhibited the replication of herpes simplex virus type 2 (HSV-2) dose-dependently by 38.5-96.1% of the control level, after incubations with 0.78-12.5 microg/ml of the polysaccharide. SP2 exhibited extracellular virucidal activity only in high concentrations (>/=12.5 microg/ml) but significantly inhibited the virus attachment to its host cells by 45.1%, at concentration as low as 1 microg/ml. All the results from this study suggested that the antiviral mode of action of SP2 could be ascribed to the inhibition of virus adsorption, which is different from that of the current drug of choice acyclovir.
从褐藻鼠尾藻中分离出一种硫酸化多糖（SP2）。在与0.78 - 12.5微克/毫升的多糖孵育后，SP2对2型单纯疱疹病毒（HSV - 2）的复制具有剂量依赖性抑制作用，抑制率达对照水平的38.5 - 96.1%。SP2仅在高浓度（≥12.5微克/毫升）时表现出细胞外杀病毒活性，但在低至1微克/毫升的浓度下就能显著抑制病毒对宿主细胞的附着，抑制率达45.1%。本研究的所有结果表明，SP2的抗病毒作用方式可能归因于对病毒吸附的抑制，这与目前的首选药物阿昔洛韦不同。
