Calkins Hugh, Canby Robert, Weiss Raul, Taylor Gregg, Wells Peter, Chinitz Larry, Milstein Simon, Compton Steven, Oleson Kimberly, Sherfesee Lou, Onufer John
Johns Hopkins Hospital, 600 North Wolfe Street, Baltimore, MD 21287-0409, USA.
Am J Cardiol. 2004 Aug 15;94(4):437-42. doi: 10.1016/j.amjcard.2004.04.058.
The purpose of this study was to evaluate the safety and efficacy of radiofrequency (RF) ablation of typical atrial flutter by using an 8-mm electrode catheter and a 100-W RF power generator. A limitation of previous trials of catheter ablation of atrial flutter is that the data were not collected as part of a prospective multicenter clinical trial. The study results associated catheter ablation of typical atrial flutter in a cohort of 150 patients with an 88% acute efficacy rate. At 6-month follow-up, recurrent typical atrial flutter was observed in 13% of patients. Of the 12 patients with typical atrial flutter recurrence, 4 were symptomatic and 8 were asymptomatic. Procedure duration was a significant predictor of typical atrial flutter recurrence. The 12-month rate for development of atrial fibrillation was 30%. Catheter ablation of atrial flutter was associated with significant improvements in 5 of 8 domains of the Short Form 36 Survey (quality of life) and significant decreases in 13 of the 16 symptoms of the Symptom Checklist. The device- or procedure-related complication rate was 2.7%. Skin burns occurred at the dispersive pad site due to stronger RF power in 3 patients. Use of a dual dispersive pad system mitigated this problem. Thus, the results of this study associated catheter ablation of atrial flutter with high acute efficacy, a small risk of recurrent atrial flutter, and an important risk of atrial fibrillation during follow-up.
本研究的目的是评估使用8毫米电极导管和100瓦射频发生器对典型心房扑动进行射频(RF)消融的安全性和有效性。先前心房扑动导管消融试验的一个局限性在于,数据并非作为前瞻性多中心临床试验的一部分收集。该研究结果显示,在150例患者队列中,典型心房扑动导管消融的急性有效率为88%。在6个月的随访中,13%的患者出现典型心房扑动复发。在12例典型心房扑动复发患者中,4例有症状,8例无症状。手术持续时间是典型心房扑动复发的重要预测因素。房颤发生的12个月发生率为30%。心房扑动导管消融与简明健康调查36项量表(生活质量)8个领域中的5个领域的显著改善以及症状自评量表16项症状中的13项显著减轻相关。器械或手术相关并发症发生率为2.7%。3例患者因射频功率较强,在分散电极垫部位出现皮肤灼伤。使用双分散电极垫系统缓解了这一问题。因此,本研究结果表明,心房扑动导管消融具有较高的急性有效性、较低的心房扑动复发风险以及随访期间发生房颤的重要风险。