Sivakumar Branavan, Harry Lorraine E, Paleolog Ewa M
Kennedy Institute of Rheumatology, Faculty of Medicine, Imperial College, London.
JAMA. 2004 Aug 25;292(8):972-7. doi: 10.1001/jama.292.8.972.
The concept of manipulation of the vascular bed to either increase or decrease the number of blood vessels has attracted considerable interest. This review focuses on angiogenesis as a therapeutic target, particularly in the context of cancer and arthritis, as well as on promoting angiogenesis in cardiovascular disease and the healing of bone fractures. Although once touted almost as a panacea for treatment of tumors, as well as other diseases associated with angiogenesis, such as diabetic retinopathy or rheumatoid arthritis, it is now clear that such enthusiasm was somewhat premature. Similarly, some clinical trials of therapeutic angiogenesis for the management of cardiovascular disease have been disappointing. Nevertheless, this exciting field of research holds promise for more targeted therapies.
通过操控血管床来增加或减少血管数量的概念已引起了相当大的关注。本综述聚焦于将血管生成作为治疗靶点，尤其是在癌症和关节炎的背景下，以及在心血管疾病和骨折愈合中促进血管生成。尽管血管生成曾一度几乎被吹捧为治疗肿瘤以及其他与血管生成相关疾病（如糖尿病性视网膜病变或类风湿性关节炎）的万灵药，但现在很明显，这种热情有些为时过早。同样，一些用于治疗心血管疾病的治疗性血管生成的临床试验也令人失望。然而，这个令人兴奋的研究领域有望实现更具针对性的治疗。
