Rajendran R, George Thomas
Department of Oral Pathology, Dental Wing, Medical College, Trivandrum--695011, India.
Indian J Dent Res. 2003 Oct-Dec;14(4):194-205.
The objective of this study was to address retrospectively the invasive tumor fronts of epithelial neoplasms associated with OSF and non-associated tumors. Review of a data base of 25 OSF patients who have had concurrent oral squamous cell carcinoma served as the test sample. The controls constituted an equal number of age standardized (roughly) squamous cell carcinomas, non-associated with OSF. The diagnsis and grading were performed based on established criteria. Altogether a total of 8 histopathological variables were evaluated related to the advancing tumor fronts. After selection of cut-off levels, single parameter analysis by means of univariate test revealed significant result in none. A Total Malignancy Score (TMS) of 14.98 and 15.13(mean) were recorded for test and control respectively. Multivariate analysis showed that degree of nuclear plemorphism (p=0.015) and the pattern of invasion (p=0.003) were the only two variables which significantly affected the TMS. OSF associated tumors did not show features unique to it and therefore its response to therapy need not vary significantly from conventional cases.
本研究的目的是回顾性地研究与口腔黏膜下纤维化（OSF）相关的上皮性肿瘤以及非相关肿瘤的浸润性肿瘤前沿。对25例并发口腔鳞状细胞癌的OSF患者的数据库进行回顾，作为测试样本。对照组为数量相等的年龄大致标准化的鳞状细胞癌患者，与OSF无关。诊断和分级依据既定标准进行。总共评估了8个与肿瘤前沿进展相关的组织病理学变量。在选择临界值后，通过单变量检验进行的单参数分析未显示出显著结果。测试组和对照组的总恶性评分（TMS）分别记录为14.98和15.13（平均值）。多变量分析表明，核多形性程度（p = 0.015）和浸润模式（p = 0.003）是仅有的两个显著影响TMS的变量。与OSF相关的肿瘤未表现出其独特的特征，因此其对治疗的反应与传统病例相比无需有显著差异。
